胶质母细胞瘤微环境中巨噬细胞极化影响因素的研究进展  

Research progress on factors influencing macrophage polarization in the microenvironment of glioblastoma

作　　者：杨晓雄 刘轩辰 张晋伟 吉宏明[1] 王春红[1] YANG Xiaoxiong;LIU Xuanchen;ZHANG Jinwei;JI Hongming;WANG Chunhong(Department of Neurosurgery,Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University,Taiyuan 030012,China)

机构地区：[1]山西医科大学附属山西省人民医院神经外科,太原030012 [2]山西医科大学附属山西省人民医院普外科,太原030012

出　　处：《临床神经外科杂志》2025年第2期219-221,225,共4页Journal of Clinical Neurosurgery

基　　金：山西省基础研究计划项目(202103021224380);山西省教育厅2024年度研究生教育创新计划项目(2024SJ177)。

摘　　要：胶质母细胞瘤(GBM)是成人群体中恶性程度最高的原发性颅内恶性肿瘤,其短生存期与肿瘤微环境导致的免疫抑制现象紧密相关,而肿瘤相关巨噬细胞(TAMs)表型的转化在构建肿瘤免疫抑制环境并驱动疾病发展中起到核心作用。本文通过检索并分析相关文献及新近研究进展,对GBM微环境中影响巨噬细胞极化的因素及其相关机制进行文献综述。Glioblastoma(GBM) is the most aggressive form of primary intracranial malignancy in adults,and its short survival duration is intricately linked to the immunosuppressive effects mediated by the tumor microenvironment.The phenotypic transition of tumor-associated macrophages(TAMs) is pivotal in establishing immunosuppressive milieu and driving the progression of the disease.This paper presents a comprehensive review of pertinent literature and emerging research developments to examine the factors governing macrophage polarization within the GBM microenvironment and the underlying mechanisms involved.

关 键 词：肿瘤相关巨噬细胞 胶质母细胞瘤 肿瘤免疫微环境 巨噬细胞极化 免疫治疗 

分 类 号：R739.41[医药卫生—肿瘤]