肠道菌群失调及外泌体在帕金森病机制中的研究进展  

Progress of intestinal flora and exosomes involved in Parkinson's disease

作　　者：罗婷 冯所芹 李波 LUO Ting;FENG Suoqin;LI Bo(School of Pharmacy,Kunming Medical University,Kunming 650500,China)

机构地区：[1]昆明医科大学药学院,昆明650500 [2]昆明医科大学研究生院

出　　处：《临床神经外科杂志》2025年第2期226-229,共4页Journal of Clinical Neurosurgery

基　　金：云南省基础研究联合专项项目(202401AY070001-064)。

摘　　要：帕金森病(PD)是一种神经退行性疾病,其发病机制至今仍未阐明。目前肠脑轴和外泌体是PD的两大研究热点,肠道菌群失调通过脑-肠轴影响机体的炎症水平、肠屏障通透性、神经炎症等参与PD的进展,而外泌体作为通讯信使参与神经胶质细胞的激活及α-syn的传递,在PD中发挥重要作用。通过综述肠道菌群、外泌体及其协同作用在PD中产生的影响,能够为PD的发生以及治疗提供一定的理论参考。Parkinson's disease(PD) is a neurodegenerative disease,and its pathogenesis has not been elucidated so far.Currently,the gut-brain axis and exosomes are the two major research hotspots in PD.The dysbiosis of intestinal flora is involved in the progression of PD through the brain-gut axis by affecting the body's inflammation level,intestinal barrier permeability,and neuroinflammation.Exosomes play an important role in PD by acting as communication messengers to participate in the activation of neuroglial cells and the transmission of α-syn.By summarizing the effects of intestinal flora,exosomes and their synergistic effects in PD,we can provide some theoretical references for the occurrence and treatment of PD.

关 键 词：帕金森病 肠脑轴 肠道菌群 外泌体 

分 类 号：R742.5[医药卫生—神经病学与精神病学]