瓜蒌薤白半夏汤对心肌细胞外基质重构机制的研究进展  

Research Progress on the Mechanism of Trichosanthes,Chinese Chive and Pinellia Decoction on Myocardial Extracellular Matrix Remodeling

作　　者：牛耘 谭颖颖[1] 张琪[1] NIU Yun;TAN Yingying;ZHANG Qi(School of Basic Medicine,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China;Comprehensive Outpatient Department,Xi'an Aircraft Design and Research Institute,AVIC,Xi'an 710089,China)

机构地区：[1]陕西中医药大学基础医学院,陕西咸阳712046 [2]中国航空工业集团公司西安飞机设计研究所综合门诊部,陕西西安710089

出　　处：《中医药学报》2025年第4期114-117,共4页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金项目(81873296)。

摘　　要：心血管疾病是全球死亡率最高的疾病之一,预防和治疗该类疾病具有重要的公共卫生意义。心肌纤维化是心血管疾病发展至终末阶段的一个共同病理表现,而心肌细胞外基质过度沉积是导致心肌纤维化的主要原因,故预防和逆转心肌细胞外基质重构,是改善心肌功能治疗心血管疾病的重要目标。瓜蒌薤白半夏汤作为中医治疗心血管系统疾病的经典名方,在治疗心血管等机制复杂的疾病方面具有显著优势。进一步探讨其对改善心肌细胞外基质重构的作用机制,有助于促进张仲景学术思想的深入研究,并为经方的配伍合理性提供科学依据,对指导临床实践也具有重要意义。Cardiovascular diseases are among the leading causes of death worldwide,making the prevention and treatment of these diseases of significant public health importance.Myocardial fibrosis is a common pathological manifestation in the advanced stages of cardiovascular diseases,with excessive deposition of myocardial extracellular matrix being a major cause of myocardial fibrosis.Therefore,preventing and reversing myocardial extracellular matrix remodeling is a critical goal in improving myocardial function and treating cardiovascular diseases.Trichosanthes,Chinese Chive and Pinellia Decoction,a classic formula in traditional Chinese medicine for treating cardiovascular diseases,demonstrates notable advantages in addressing complex mechanisms of such diseases.Further exploration of its mechanism in improving myocardial extracellular matrix remodeling will contribute to a deeper understanding of Zhang Zhongjing's academic thoughts,provide scientific evidence for the rationality of classic formula combinations,and offer important guidance for clinical practice.

关 键 词：瓜蒌薤白半夏汤 心肌细胞外基质 心肌纤维化 心血管疾病 

分 类 号：R256.22[医药卫生—中医内科学]