1972—2021年江苏省启东市胆囊癌发病趋势分析  

Trend of Incidence Rates of Gallbladder Cancer in Qidong City of Jiangsu Province from 1972 to 2021

作　　者：徐源佑 张永辉 丁璐璐 陈永胜 王军 严永锋 陈建国 朱健 XU Yuanyo;ZHANG Yonghui;DING Lulu;CHEN Yongsheng;WANG Jun;YAN Yongfeng;CHEN Jianguo;ZHU Jian(Qidong People's Hospital/Qidong Liver Cancer Institute/the Affiliated Qidong Hospital of Nantong University,Qidong 226200,China)

机构地区：[1]启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院,江苏启东226200

出　　处：《中国肿瘤》2025年第4期290-296,共7页China Cancer

基　　金：南通市“十四五”科教强卫工程(通卫科技[2021]15号);南通市卫生健康委员会科研课题(MS2023121)。

摘　　要：[目的]分析江苏省启东市1972—2021年全人群胆囊癌发病率。[方法]使用来自启东市肿瘤登记数据库里的1972—2021年胆囊癌的发病资料,计算粗发病率(crude rate,CR)、中国人口标化率(age-standardized rate by Chinese standard population,ASRC)、世界人口标化率(age-standardized rate by world standard population,ASRW)等统计指标。用Joinpoint 4.9.1.0软件进行趋势分析,计算胆囊癌发病率平均年度变化百分比(average annual percentage change,AAPC),对胆囊癌总体发病率、分性别及分年龄别发病率作时间趋势分析。[结果]启东市1972—2021年胆囊癌共发病1 369例,占全部恶性肿瘤发病的0.93%;50年间胆囊癌总CR为2.44/10万,ASRC为0.88/10万,ASRW为1.45/10万,35~64岁截缩发病率为1.98/10万,0~74岁累积发病率为0.16%,累积发病风险为0.16%。女性CR高于男性,但标化后男性略高于女性,CR、ASRC和ASRW的男女性别比依次为0.89∶1、1.07∶1和1.06∶1。随着年龄的增长,胆囊癌发病率也不断增加。50年间胆囊癌发病年龄略有提升。胆囊癌总体、男女性以及各个年龄组的发病率在50年间均有明显的上升趋势。[结论] 50年间启东市全人群胆囊癌的发病率有明显的上升趋势,应当继续重视尤其是针对重点人群开展胆囊癌的防治研究。[Purpose] To analyze the trend of incidence rates of gallbladder cancer in Qidong City of Jiangsu Province from 1972 to 2021.[Methods] The incidence data of gallbladder cancer from1972 to 2021 were collected from the Qidong Tumour Registry database,the crude incidence rate(CR),age-standardized rate by Chinese standard population(ASRC),age-standardized rate by world standard population(ASRW) of gallbladder cancer were calculated.Trend analysis was performed using Joinpoint 4.9.1.0 software to calculate the average annual percentage change(AAPC)of gallbladder cancer incidence rates,and time trend analysis was performed on the overall incidence rate by sex and age.[Results] A total of 1 369 cases of gallbladder cancer occurred in Qidong City from 1972 to 2021,accounting for 0.93% of all malignant tumors.The overall CR of gallbladder cancer was 2.44/105in 50 years,ASRC was 0.88/105and ASRW was 1.45/105.The truncated rate of 35~64 years old was 1.98/105,the cumulative incidence of gallbladder cancer at0~74 years old was 0.16%,and the risk of cumulative incidence of gallbladder cancer was 0.16%.CR was slightly higher in women than that in men,but after standardization it was slightly higher in men than that in women.The sex ratio of CR,ASRC and ASRW was 0.89,1.07 and 1.06,respectively.With the increase of age,the incidence of gallbladder cancer was also increased.The age of onset was slightly increased in last 50 years.In last 50 years,there was an upward trend in the overall incidence of gallbladder cancer,the incidence both for men and women,and the incidence of each age group.[Conclusion] The incidence of gallbladder cancer in Qidong City has increased considerably during the past 50 years,and continuing attention should be paid to the prevention and treatment of gallbladder cancer especially for the key populations.

关 键 词：胆囊癌 肿瘤登记 发病率 趋势 江苏 

分 类 号：R73-31[医药卫生—肿瘤] R735.8[医药卫生—临床医学]