1972—2021年江苏省启东市非霍奇金淋巴瘤发病趋势分析  

Trend of Non-Hodgkin's Lymphoma Incidence in Qidong City of Jiangsu Province from 1972 to 2021

作　　者：王军 陈永胜 樊健 朱健 WANG Jun;CHEN Yongsheng;FAN Jian;ZHU Jian(Qidong People's Hospital/Qidong Liver Cancer Institute/Qidong Hospital Affiliated to Nantong University,Qidong 226200,China)

机构地区：[1]启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院,江苏启东226200

出　　处：《中国肿瘤》2025年第4期297-303,共7页China Cancer

基　　金：南通市“十四五”科教强卫工程(通卫科技[2021]15号);南通市卫生健康委员会科研课题(MS2023121)。

摘　　要：[目的]分析江苏省启东市1972—2021年非霍奇金淋巴瘤发病流行趋势。[方法]提取启东市肿瘤登记处1972—2021年非霍奇金淋巴瘤发病登记资料,计算粗发病率、中国人口标准化发病率(中标率)、世界人口标准化发病率(世标率)、35~64岁截缩发病率和0~74岁累积发病率等。年龄-时期-队列模型分析非霍奇金淋巴瘤发病率的年龄、时期和队列效应;采用Joinpoint 4.9.1.0软件进行趋势分析,计算非霍奇金淋巴瘤发病率的平均年度变化百分比(average annual percentage change,AAPC)。[结果]1972—2021年启东市非霍奇金淋巴瘤共计发病2681例,粗发病率为4.78/10万,中标发病率为3.35/10万,世标发病率为3.30/10万,35~64岁截缩发病率为5.20/10万,0~74岁累积发病率为0.37%。男性发病1589例,粗发病率、中标率、世标率分别为5.75/10万、4.19/10万、4.14/10万;女性发病1092例,粗发病率、中标率、世标率分别为3.84/10万、2.60/10万、2.54/10万。年龄-时期-队列分析显示,非霍奇金淋巴瘤发病率的净漂移值为1.65(95%CI:1.19~2.11),年龄、时期和队列效应均为非霍奇金淋巴瘤发病率的重要影响因素,差异均有统计学意义(P均<0.05)。1972—2021年启东市非霍奇金淋巴瘤中标率男女合计、男性和女性的AAPC分别为1.71%(95%CI:0.88%~2.54%,t=4.07)、1.62%(95%CI:1.14%~2.11%,t=6.77)和2.01%(95%CI:0.77%~3.26%,t=3.19),上升趋势显著,差异均有统计学意义(P均<0.01)。[结论]启东市非霍奇金淋巴瘤50年来标化发病率整体呈现上升趋势,男性发病率高于女性,老年人群发病率高,应重视老年人群和男性非霍奇金淋巴瘤的防治和健康教育。[Purpose]To analyze the trend of non-Hodgkin's lymphoma incidence in Qidong City of Jiangsu Province from 1972 to 2021.[Methods]The data of non-Hodgkin's lymphoma incidence collected from Qidong Cancer Registry from 1972 to 2021 were extracted.The crude incidence rate(CR),age-standardized rate by Chinese standard population(ASRC)and by world standard population(ASRW),truncated incidence rate(35~64 years old)and cumulative incidence rate(0~74 years old)were calculated.The age-period-cohort model was used to analyze the age,period,and cohort effects of incidence in non-Hodgkin's lymphoma.Joinpoint 4.9.1.0 software was used to calculate the average annual percentage change(AAPC)of non-Hodgkin's lymphoma incidence for trend analysis.[Results]There were a total of 2681 cases of non-Hodgkin's lymphoma reported in Qidong from 1972 to 2021.The CR,ASRC,ASRW,the truncated incidence(35~64years old)rate and cumulative incidence rate(0~74 years old)were 4.78/105,3.35/105,3.30/105,5.20/105and 0.37%,respectively.There were 1589 male cases,with CR,ASRC and ASRW of5.75/105,4.19/105and 4.14/105,respectively;and there were 1092 female cases,with CR,ASRC and ASRW of 3.84/105,2.60/105and 2.54/105,respectively.Age-period-cohort analysis showed that the net drift value of non-Hodgkin's lymphoma incidence was 1.65(95%CI:1.19~2.11),and age,period and cohort effects were all important influencing factors of non-Hodgkin's lymphoma incidence rate(all P<0.05).The AAPCs for both sex,male and female of ASRC of non-Hodgkin's lymphoma in Qidong from 1972 to 2021 were 1.71%(95%CI:0.88%~2.54%,t=4.07),1.62%(95%CI:1.14%~2.11%,t=6.77),and 2.01%(95%CI:0.77%~3.26%,t=3.19),respectively,with a significant upward trend,and the differences were statistically significant(all P<0.01).[Conclusion]Non-Hodgkin's lymphoma in Qidong City shows an overall increasing trend in the age-standardized incidence over the past 50 years,with a higher incidence in male and in the elderly population.

关 键 词：非霍奇金淋巴瘤 发病 年龄-时期-队列模型 趋势 江苏 

分 类 号：R73-31[医药卫生—肿瘤] R733[医药卫生—临床医学]