中国FLASH放射疗法快速发展的机遇和挑战  

Opportunities and Challenges for the Rapid Development of FLASH Radiotherapy in China

作　　者：罗辉 杨成梁 葛红 LUO Hui;YANG Chengliang;GE Hong(Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450008,China)

机构地区：[1]郑州大学附属肿瘤医院,河南郑州450008

出　　处：《中国肿瘤》2025年第4期326-330,共5页China Cancer

摘　　要：近年来,FLASH放射疗法(FLASH radiotherapy,FLASH-RT)作为国际上一种尖端放疗技术,理论研究和临床试验发展迅速。FLASH-RT能够在极短时间(通常≤500 ms)内实施超高剂量率(平均剂量率≥40 Gy/s,瞬时剂量率≥100 Gy/s)照射,在保持相同肿瘤控制率的前提下,正常组织损伤小于同剂量的常规剂量率照射,即FLASH效应。FLASH-RT具有独特的放射生物学优势,是目前国际放射肿瘤学界的前沿领域。中国在FLASH-RT的研发和临床试验方面取得了飞跃式的进展,成为重要的参与者。全文对中国FLASH-RT面临的新挑战和机遇进行了全面的阐述。In recent years,FLASH radiotherapy(FLASH-RT),as a cutting-edge radiotherapy technology,has developed rapidly in basic research and clinical trials.FLASH-RT can deliver ultra-high dose rate(average dose rate≥40 Gy/s,instantaneous dose rate≥100 Gy/s)irradiation in a very short time(usually≤500 ms).Under the premise of maintaining equivalent tumor control rates,the normal tissue injury is less than that of conventional irradiation at the same dose,that is known as the FLASH effect.FLASH-RT has unique advantages and is currently the frontier field of radiation oncology.The research and development of FLASH-RT have progressed rapidly in China,this paper elucidated the new challenges and opportunities of FLASH-RT in China.

关 键 词：FLASH放疗 临床研究 机遇 挑战 中国 

分 类 号：R730.55[医药卫生—肿瘤]