多功能ADC药物的设计、合成与药理学评价研究  

Research on the design,synthesis,and pharmacological evaluation of multi functional ADC drugs

作　　者：王凯 WANG Kai(Nanjing Yuanshu Medical Technology Co.,Ltd.,Nanjing 210033,China)

机构地区：[1]南京远淑医药科技有限公司,江苏南京210033

出　　处：《化工管理》2025年第10期125-128,共4页Chemical Management

摘　　要：文章系统评述了多功能ADC药物的设计、合成及药理学评价。首先,介绍了ADC药物的概念和在肿瘤治疗中的重要性,阐述了多功能ADC药物设计的策略,包括选择合适的抗体、药物连接部位和药物负载等;其次,探讨了多功能ADC药物的合成方法,特别是介绍了最新的合成技术和优化策略;再次,综述了多功能ADC药物在体内的药理学评价方法,如药代动力学、药效学和安全性评估;最后,对多功能ADC药物的未来发展趋势和挑战进行了展望,提出了加强合作、优化合成技术和深入研究机制等建议,以推动该领域的进一步发展。This paper systematically reviews the design,synthesis,and pharmacological evaluation of multifunctional ADC drugs.Firstly,the concept of ADC drugs and their importance in tumor treatment were introduced,and the strategies for designing multifunctional ADC drugs were elaborated,including selecting appropriate antibodies,drug connection sites,and drug loading;Secondly,the synthesis methods of multifunctional ADC drugs were discussed,especially the latest synthesis techniques and optimization strategies were introduced.Once again,the pharmacological evaluation methods of multifunctional ADC drugs in vivo,such as pharmacokinetics,pharmacodynamics,and safety assessment,were reviewed.F inally,the future development trends and challenges of multifunctional ADC drugs were discussed,and suggestions were put forward to strengthen cooperation,optimize synthesis techniques,and conduct in-depth research on mechanisms to promote further development in this field.

关 键 词：多功能抗体药物偶联物 药物设计 化学合成 药理学评价 肿瘤治疗 

分 类 号：R96[医药卫生—药理学]