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作 者:周文逊 仲照希[2] 魏红军 ZHOU Wen-xun;ZHONG Zhao-xi;WEI Hong-jun(Department of Psychiatry,Xiping Kangya Psychiatric Hospital,Zhumadian 463900,Henan Province,China;Department of Psychiatry,Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)
机构地区:[1]西平康雅精神病医院精神科,河南驻马店463900 [2]新乡医学院第二附属医院精神科,河南新乡453002
出 处:《罕少疾病杂志》2025年第4期12-14,共3页Journal of Rare and Uncommon Diseases
摘 要:目的探讨丙戊酸钠缓释片联合盐酸齐拉西酮治疗双向情感障碍躁狂发作的有效性和安全性。方法选取2019年1月至2022年12月在本院就诊的双向情感障碍躁狂发作患者160例,按照1:1比例分配,随机分组,即对照组、观察组,均80例。两组均进行常规治疗,对照组在常规治疗的基础上采用丙戊酸钠缓释片,观察组在对照组的基础上增加盐酸齐拉西酮。统计两组BRMS评分、临床疗效、神经递质水平、不良反应发生情况。结果治疗前,两组BRMS评分比较,P>0.05,治疗后,两组BRMS评分均较治疗前下降,组间比较,观察组BRMS评分低于对照组,P<0.05;观察组临床总有效率95.00%高于对照组,P<0.05;治疗前,两组神经递质水平比较,P>0.05,治疗后,两组神经递质水平均较治疗前下降,P<0.05,组间比较,观察组神经递质水平低于对照组,P<0.05;两组患者不良反应发生情况比较,P>0.05。结论丙戊酸钠缓释片联合盐酸齐拉西酮治疗双向情感障碍躁狂发作在有效性和安全性方面表现出显著优势。Objective To investigate the efficacy and safety of sodium valproate sustained-release tablets combined with ziprasidone hydrochloride in the treatment of bipolar disorder manic episode.Methods A total of 160 patients with bipolar manic episode who were admitted to our hospital from January 2019 to December 2022 were selected and randomly assigned according to 1:1 ratio,that is,80 patients in both control group and observation group.Both groups received conventional treatment,the control group was given valproate sustained-release tablets on the basis of conventional treatment,and the observation group was given ziprasidone hydrochloride on the basis of control group.The BRMS score,clinical efficacy,neurotransmitter level and adverse reactions of the two groups were analyzed.Results Before treatment,the BRMS score of the two groups was compared,P>0.05.After treatment,the BRMS score of the two groups was lower than that before treatment,and the BRMS score of the observation group was lower than that of the control group,P<0.05.The total clinical effective rate of observation group was 95.00%higher than that of control group,P<0.05;Before treatment,the level of neurotransmitter in the two groups was compared,P>0.05;after treatment,the level of neurotransmitter in the two groups was decreased compared with that before treatment,P<0.05;compared between groups,the level of neurotransmitter in the observation group was lower than that in the control group,P<0.05.The incidence of adverse reactions between the two groups was compared,P>0.05.Conclusion Sodium valproate sustained-release tablets combined with ziprasidone hydrochloride in the treatment of bipolar disorder manic episode showed significant advantages in efficacy and safety.
关 键 词:双向情感障碍 躁狂发作 丙戊酸钠缓释片 盐酸齐拉西酮 有效性 安全性
分 类 号:R749.4[医药卫生—神经病学与精神病学]
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