评估术前血清VEGF与系统性免疫炎症指数对原发性肝癌术后预后的预测价值  

Assessment of the Predictive Value of Preoperative Serum VEGF and Systemic Immunoinflammatory Index for Postoperative Prognosis of Primary Hepatocellular Carcinoma

作　　者：王爽 张彬 黄利 WANG Shuang;ZHANG Bin;HUANG Li(Nanyang First People's Hospital,Nanyang 473000,Henan Province,China;Nanyang Rehabilitation Hospital,Nanyang 473599,Henan Province,China)

机构地区：[1]南阳市第一人民医院,河南南阳473000 [2]南阳市康复医院,河南南阳473599

出　　处：《罕少疾病杂志》2025年第4期84-86,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20191981)。

摘　　要：目的探讨血管内皮生长因子(VEGF)与全身炎症指数(SⅡ)在原发性肝癌(PHC)术后的预后价值。方法回顾性分析2018年1月至2020年1月在本院进行手术治疗的164例PHC患者的临床资料。使用Logistic回归模型分析PHC患者术后复发的影响因素。采用受试者工作特征曲线(ROC)分析危险因素在预测患者复发的价值。结果Logistic回归分析显示,年龄、Child-pugh B级、VEGF、SⅡ和AFP是PHC患者术后独立的复发危险因素(P<0.05)。ROC曲线分析显示,VEGF(AUC=0.791)和SⅡ(AUC=0.687)可以预测PHC患者的术后复发,并且VEGF的AUC与联合曲线比较无差异(P>0.05)。结论年龄、Child-pugh B级、VEGF、SII和甲胎蛋白是影响患者独立预后的因素,VEGF的表达可作为PHC患者术后的复发的潜在预测指标。Objective To investigate the prognostic value of vascular endothelial growth factor(VEGF)and systemic immune-inflammation index(SⅡ)in the postoperative period of(PHC)primary hepatic carcinoma prognostic value after surgery.Methods The clinical data of 164 PHC patients who underwent surgical treatment in our hospital from January 2018 to January 2020 were retrospectively analyzed.Logistic regression model was used to analyze the influencing factors of postoperative recurrence in PHC patients.The value of risk factors in predicting patient recurrence was analyzed using Receiver operating characteristic curve(ROC).Results Logistic regression analysis showed that age,Child-pugh class B,VEGF,SII and AFP were independent risk factors for postoperative recurrence in patients with PHC(P<0.05).ROC curve analysis showed that VEGF(AUC=0.791)and SII(AUC=0.687)predicted the postoperative recurrence in patients with PHC,and There was no difference between the AUC of VEGF and the combined curve(P>0.05).Conclusion Age,Child-pugh class B,VEGF,SII and alpha-fetoprotein were the independent prognostic factors,and the expression of VEGF could be a potential predictor of postoperative recurrence in PHC patients.

关 键 词：原发性肝癌 血管内皮生长因子 全身炎症指数 术后复发 

分 类 号：R735.7[医药卫生—肿瘤]