奥美拉唑联合克拉霉素治疗萎缩性胃炎疗效及对胃黏膜病理评分的影响  

Efficacy of Omeprazole and Clarithromycin in Treating Atrophic Gastritis and Its Effect of Pathological Score on Gastric Mucosa in Patients

作　　者：王孟蝶 WANG Meng-die(Department of Gastroenterology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)

机构地区：[1]河南科技大学第一附属医院消化内科,河南洛阳471000

出　　处：《罕少疾病杂志》2025年第4期121-123,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨奥美拉唑联合克拉霉素治疗萎缩性胃炎(CAG)的疗效及对患者胃黏膜病理评分的影响。方法将2021年9月至2023年6月我院收治的220例CAG患者采用随机数余数分组法分为单纯抑酸组和联合用药组,各110例。单纯抑酸组应用奥美拉唑治疗,联合用药组联合应用克拉霉素治疗。对比两组患者的临床疗效、胃蛋白酶原(PG)水平、胃黏膜病理评分、用药安全性。结果联合用药组临床疗效较单纯抑酸组高,差异有统计学意义(90.90%vs79.09%,P<0.05)。治疗后两组患者血清中胃蛋白酶原Ⅰ(PGⅠ)水平、胃蛋白酶原Ⅱ(PGⅡ)水平和胃蛋白酶原Ⅰ与胃蛋白酶原Ⅱ比值(PGR)均较治疗前改善,且联合用药组较单纯抑酸组改善程度高,差异有统计学意义(P<0.05)。治疗后两组患者胃黏膜病理评分较治疗前降低,且联合用药组低于单纯抑酸组(P<0.05)。两组总不良反应发生率比较无显著差异(10.91%vs16.36%,P>0.05)。结论奥美拉唑联合克拉霉素可有效改善CAG患者的临床疗效,改善患者胃肠激素水平,降低患者胃黏膜病理评分,且不会明显增加药物不良反应,推荐临床应用。Objective To investigate the effect of omeprazole and clarithromycin in treating atrophic gastritis(chronic atrophicgastritis,CAG)and its effect on the pathological score of gastric mucosa.Methods The 220 CAG patients admitted to September 2021 to June 2023 were divided into 110 patients each.The acid suppression group was treated with omeprazole and the combination group was treated with clarithromycin.The clinical efficacy,pepsinogen(PG)level,gastric mucosal pathology score,and drug safety of the two groups were compared.Results The clinical efficacy of the combination group was higher than the acid suppression group(90.90%vs79.09%,P<0.05).After treatment,pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),and pepsinⅠto pepsin ratio(PGR)improved compared with the treatment compared with the combination group(P<0.05).After treatment,the gastric mucosa in both groups decreased compared with before treatment,and the combination group was lower than the group with acid suppression alone(P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(10.91%vs16.36%,P>0.05).Conclusion Omeprazole combined with clarithromycin can effectively improve the clinical efficacy of CAG patients,improve the gastrointestinal hormone level,reduce the gastric mucosa pathological score of patients,and do not significantly increase the adverse drug reactions,so the clinical application is recommended.

关 键 词：奥美拉唑 克拉霉素 萎缩性胃炎 胃黏膜 

分 类 号：R573.32[医药卫生—消化系统]