醒脑静注射液在急性脑梗死介入治疗围术期中的应用效果及对氧化应激反应、神经功能缺损的影响  

Application effect of Xingnaojing injection in the perioperative period of interventional therapy for acute cerebral infarction and its influences on oxidative stress response and neurological deficits

作　　者：吴伟 董凤君 WU Wei;DONG Fengjun(the First People's Hospital of Lingbao,Sanmenxia 472500,China)

机构地区：[1]灵宝市第一人民医院,河南三门峡472500

出　　处：《临床医学研究与实践》2025年第11期134-138,共5页Clinical Research and Practice

摘　　要：目的探讨醒脑静注射液在急性脑梗死介入治疗围术期中的应用效果及对氧化应激反应、神经功能缺损的影响。方法选取2019年8月至2022年3月本院收治的拟行介入治疗的87例急性脑梗死患者,采用随机数字表法将其分为A组(43例)与B组(44例)。A组在急性脑梗死介入治疗围术期中应用丁苯酞注射液治疗,B组在急性脑梗死介入治疗围术期中应用醒脑静注射液治疗。比较两组的治疗效果。结果两组的血管再通率比较,差异无统计学意义(P>0.05)。治疗14 d后,B组的丙二醛(MDA)水平低于A组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平高于A组,差异具有统计学意义(P<0.05)。治疗14 d后,B组的美国国立卫生研究院卒中量表(NIHSS)评分明显低于A组(P<0.05)。B组的治疗总有效率明显高于A组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论急性脑梗死介入治疗围术期应用醒脑静注射液可明显减轻氧化应激反应及神经功能缺损,提高临床疗效,且安全性良好,具有推广应用价值。Objective To investigate the application effect of Xingnaojing injection in the perioperative period of interventional therapy for acute cerebral infarction and its influences on oxidative stress response and neurological deficit.Methods A total of 87 patients with acute cerebral infarction who underwent interventional therapy in our hospital from August 2019 to March 2022 were selected and divided into group A(43 cases)and group B(44 cases)by random number table method.The group A was treated with butylphthalide injection during the perioperative period of interventional therapy for acute cerebral infarction,and the group B was treated with Xingnaojing injection during the perioperative period of interventional therapy for acute cerebral infarction.The therapeutic effects of the two groups were compared.Results There was no significant difference in vascular recanalization rate between the two groups(P>0.05).After 14 d of treatment,the level of malondialdehyde(MDA)in the group B was lower than that in the group A,and the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the group B were higher than those in the group A,the differences were statistically significant(P<0.05).After 14 d of treatment,the National Institutes of Health Stroke Scale(NIHSS)score of the group B was significantly lower than that of the group A(P<0.05).The total effective rate of treatment in the group B was significantly higher than that in the group A(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Xingnaojing injection applied in the perioperative period of interventional therapy for acute cerebral infarction can significantly reduce oxidative stress response and neurological deficit,improve clinical efficacy,and has good safety.It has the value of popularization and application.

关 键 词：急性脑梗死 介入治疗 围术期 醒脑静注射液 氧化应激 神经功能 

分 类 号：R741[医药卫生—神经病学与精神病学]