胃动蛋白2、趋化因子17和细胞角蛋白19片段抗原21-1在胃癌中的表达及其临床意义  

Expression of Gastrokine 2,Chemokine 17,and Cytokeratin 19 Fragment Antigen 21-1 in Gastric Cancer and Their Clinical Significance

作　　者：程振 冶鹏娟 朱彦杰 CHENG Zhen;YE Pengjuan;ZHU Yanjie(Department of Pathology,Kaifeng Central Hospital,Kaifeng Henan 475000,China;Department of Hematology,Kaifeng Central Hospital,Kaifeng Henan 475000,China)

机构地区：[1]开封市中心医院病理科,河南开封475000 [2]开封市儿童医院血液内科,河南开封475000

出　　处：《临床研究》2025年第4期1-4,共4页Clinical Research

摘　　要：目的探讨胃动蛋白2(GKN2)、趋化因子17(CCL17)、细胞角蛋白19片段抗原21-1(CYFRA21-1)表达情况与胃癌患者病理特征及预后的关系。方法选取2020年1月至2021年1月期间在开封市中心医院就诊并经手术病理学证实为胃癌的80例患者作为胃癌组,另选取同一时期体检健康的50例患者作为健康对照组。收集所有研究对象的胃部组织标本,检测各组织标本中GKN2、CCL17、CYFRA21-1表达,并分析上述指标不同表达与胃癌患者病理特征及生存时间的关系。结果胃癌组GKN2阳性表达率明显低于健康对照组,胃癌组CCL17、CYFRA21-1阳性表达率均明显高于健康对照组,差异均有统计学意义(P<0.05)。不同肿瘤组织分化程度GKN2、CCL17、CYFRA21-1表达水平比较,差异无统计学意义(P>0.05),胃癌患者是否有淋巴结转移、不同肿瘤直径及TNM分期GKN2、CCL17、CYFRA21-1表达水平比较,差异均有统计学意义(P<0.05);不同GKN2、CCL17、CYFRA21-1表达水平生存曲线不同,其中GKN2低表达患者生存率较低,生存时间较短,GKN2高表达患者生存率较高,生存时间较长;CCL17、CYFRA21-1低表达患者生存率均较高,生存时间均较长,CCL17、CYFRA21-1高表达患者生存率均较低,生存时间均较短。多元回归分析结果显示,CYFRA21-1的表达情况是患者发生淋巴结转移、肿瘤直径及TNM分期的影响因子。结论胃癌组织中GKN2阳性表达率较低,CCL17、CYFRA21-1阳性表达率较高,CYFRA21-1的表达情况是胃癌患者发生淋巴结转移、肿瘤直径、TNM分期的影响因子,并以此影响到胃癌患者的预后。Objective To investigate the expression of gastrokine 2(GKN2),chemokine 17(CCL17),and cytokeratin 19 fragment antigen 21-1(CYFRA21-1)in gastric cancer and their relationship with the pathological characteristics and prognosis of patients.Methods Eighty patients diagnosed with gastric cancer by surgical pathology at Kaifeng Central Hospital from January 2020 to January 2021 were selected as the gastric cancer group.Another 50 patients with healthy check-ups during the same period were chosen as the healthy control group.Gastric tissue specimens from all subjects were collected to detect the expression of GKN2,CCL17,and CYFRA21-1.The relationship between the expression of these markers,the pathological characteristics of gastric cancer,and patient survival was analyzed.Results The positive expression rate of GKN2 in the gastric cancer group was significantly lower than that in the healthy control group,whereas the positive expression rates of CCL17 and CYFRA21-1 were significantly higher,with all differences being statistically significant(P<0.05).There were no statistically significant differences in the expression levels of GKN2,CCL17,and CYFRA21-1 across different tumor differentiation degrees(P>0.05);however,significant differences were found with lymph node metastasis,tumor diameter,and TNM staging(P<0.05).Survival curves differed according to GKN2,CCL17,and CYFRA21-1 expression levels.Patients with low GKN2 expression had lower survival rates and shorter survival times,whereas those with high GKN2 expression had higher survival rates and longer survival times.Patients with low CCL17 and CYFRA21-1 expression had higher survival rates and longer survival times,while those with high expression had lower survival rates and shorter survival times.Multiple regression analysis showed that CYFRA21-1 expression was an influencing factor for lymph node metastasis,tumor diameter,and TNM stage in gastric cancer patients.Conclusion The expression rate of GKN2 is low,while the expression rates of CCL17 and CYFRA21-1 are hi

关 键 词：胃癌 病理特征 胃动蛋白2 趋化因子17 细胞角蛋白19片段抗原 预后 

分 类 号：R735.2[医药卫生—肿瘤]