血栓弹力图在指导非小细胞肺癌患者围术期非红细胞输血的应用研究  

Application Study of Thromboelastography in Guiding Non-Erythrocyte Blood Transfusion During the Perioperative Period in Patients with Non-Small Cell Lung Cancer

作　　者：梅懿文 MEI Yiwen(Transfusion Department,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院输血科,河南南阳473000

出　　处：《临床研究》2025年第4期65-68,共4页Clinical Research

摘　　要：目的探究血栓弹力图(TEG)指导非小细胞肺癌(NSCLC)患者围术期非红细胞输血的价值。方法回顾性分析2022年11月至2024年3月南阳市中心医院收治的62例NSCLC患者的临床资料,依据围术期非红细胞输血的指导模式的不同分为对照组(31例,血常规凝血检测指导)与研究组(31例,TEG指导)。比较两组患者围术期成分输血用量情况、治疗效果,并分析TEG情况。结果研究组患者新鲜冰冻血浆、冷沉淀凝血因子、血小板用量少于对照组,差异有统计学意义(P<0.05)。研究组患者术后住院时间短于对照组,术后15 d病死率低于对照组,差异有统计学意义(P<0.05)。围术期接受成分输血研究样本中,当样本发生血栓后,TEG异常凝血功能图形表现较为明显,且当进行成分输血治疗后,TEG的图形表现会逐渐恢复为正常凝血功能图形。结论TEG指导NSCLC患者围术期非红细胞输血的效果较为理想,可用于指导正确选用血制品类型,同时合理调节其输注用量,进而缩短术后住院时间及降低术后15 d病死率,具有临床应用价值。Objective To explore the value of thromboelastography(TEG)in guiding non-erythrocyte blood transfusion during the perioperative period in patients with non-small cell lung cancer(NSCLC).Methods A retrospective analysis was conducted on the clinical data of 62 patients with NSCLC treated at Nanyang Central Hospital from November 2022 to March 2024.Based on the different guidance modes for perioperative non-erythrocyte blood transfusion,patients were divided into a control group(31 cases,guided by routine blood coagulation tests)and a study group(31 cases,guided by thromboelastography).The amounts of component transfusion and treatment outcomes during the perioperative period were compared between the two groups,and thromboelastography results were analyzed.Results The amounts of fresh frozen plasma,cryoprecipitate clotting factors,and platelets used in the study group were less than those in the control group,with statistically significant differences(P<0.05).The duration of postoperative hospitalization in the study group was shorter than that in the control group,and the 15-day postoperative mortality rate in the study group was lower than that in the control group,with statistically significant differences(P<0.05).Among the study samples receiving component transfusions,those that developed thrombosis showed pronounced abnormal coagulation profiles on thromboelastography,and the thromboelastography profiles gradually returned to normal following component transfusion treatment.Conclusion Thromboelastography is effective in guiding non-erythrocyte blood transfusion during the perioperative period in patients with non-small cell lung cancer.It can assist in the correct selection of blood product types,rationally adjust their infusion volumes,thereby shortening postoperative hospitalization and reducing the 15-day postoperative mortality rate,demonstrating clinical application value.

关 键 词：NSCLC TEG 围术期 非红细胞输血 

分 类 号：R734.2[医药卫生—肿瘤]