富马酸伏诺拉生联合莫沙必利治疗反流性食管炎的效果  

Effect of Vonoprazan Fumarate Combined with Mosapride in Treatment of Reflux Esophagitis

作　　者：喻金波 李中华 魏丽花 YU Jinbo;LI Zhonghua;WEI Lihua(Department of Pharmacy,Shangrao People's Hospital,Shangrao 334000,China)

机构地区：[1]上饶市人民医院药剂科,江西上饶334000 [2]上饶市人民医院消化内科,江西上饶334000

出　　处：《中国医学创新》2025年第11期99-103,共5页Medical Innovation of China

摘　　要：目的:探究富马酸伏诺拉生联合莫沙必利治疗反流性食管炎的效果。方法:按照随机数字表法将2023年1月—2024年4月上饶市人民医院收治的80例反流性食管炎患者分为两组,各40例。对照组采用富马酸伏诺拉生治疗,观察组在对照组基础上加用莫沙必利治疗。对比两组临床疗效、不良反应,治疗前后实验室指标及疾病指标。结果:治疗后,观察组胃肠激素、炎症因子及疾病指标均优于对照组,差异均有统计学意义(P<0.05);治疗后,观察组总有效率高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:富马酸伏诺拉生联合莫沙必利治疗反流性食管炎的效果较好,可调节机体实验室指标,缓解临床症状,促进机体康复,降低炎症因子水平,调节胃肠激素水平。Objective:To observe the effect of Vonoprazan Fumarate combined with Mosapride in the treatment of reflux esophagitis.Method:According to the random number table method,80 patients with reflux esophagitis admitted to Shangrao People's Hospital from January 2023 to April 2024 were divided into two groups,with 40 cases each.The control group was treated with Vonoprazan Fumarate,and the observation group was treated with Mosapride on the basis of control group.The clinical efficacy,adverse reactions,laboratory indexes and disease indexes before and after treatment were compared between the two groups.Result:After treatment,gastrointestinal hormones,inflammatory factors and disease indicators in the observation group were better than those in the control group,with statistical significance(P<0.05).After treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Vonoprazan Fumarate combined with Mosapride has a good effect in the treatment of reflux esophagitis,which can regulate laboratory indexes,relieve clinical symptoms,promote body rehabilitation,reduce the level of inflammatory factors and regulate the level of gastrointestinal hormones.

关 键 词：富马酸伏诺拉生 莫沙必利 反流性食管炎 不良反应 

分 类 号：R571[医药卫生—消化系统]