摩罗丹+改良四联序贯疗法在Hp阳性慢性萎缩性胃炎中的应用效果  

The Application Effect of Moluodan+Modified Quadruple Sequential Therapy in Hp-positive Chronic Atrophic Gastritis

作　　者：伍沁芳 杨晓薇[1] 成诚[1] WU Qinfang;YANG Xiaowei;CHENG Cheng(Department of Gastroenterology,Jiujiang NO.1 People's Hospital,Jiujiang 332000,China;不详)

机构地区：[1]九江市第一人民医院消化内科,江西九江332000

出　　处：《中国医学创新》2025年第12期9-13,共5页Medical Innovation of China

摘　　要：目的:探究摩罗丹+改良四联序贯疗法对幽门螺杆菌(Helicobacter pylori,Hp)阳性慢性萎缩性胃炎(chronic atrophic gastritis,CAG)的疗效及炎症因子的影响。方法:采用随机数字表法将96例2021年3月—2024年3月在九江市第一人民医院就诊的CAG患者分为观察组和对照组,各48例。对照组采用改良四联序贯疗法治疗,观察组在对照组的基础上加用摩罗丹。统计治疗14 d后的临床疗效及治疗后1个月的Hp转阴率;统计治疗前后炎症因子水平和血清指标;统计治疗期间的不良反应情况。结果:观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和C反应蛋白(CRP)水平均低于治疗前和对照组,差异均有统计学意义(P<0.05);观察组胃蛋白酶原Ⅰ(PGⅠ)、胃泌素(GAS)水平均高于治疗前和对照组,差异均有统计学意义(P<0.05),两组胃蛋白酶原Ⅱ(PGⅡ)水平比较,差异无统计学意义(P>0.05)。治疗后1个月,观察组共38例Hp转阴,转阴率为79.17%;对照组共29例Hp转阴,转阴率为60.42%,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:摩罗丹与改良四联序贯法联合治疗Hp阳性CAG的效果显著,降低炎症因子分泌的同时还可以增加患者的Hp转阴率,安全性较高。Objective:To investigate the efficacy of Moluodan+modified quadruple sequential therapy on Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG)and the effect on inflammatory factor.Method:A total of 96 CAG patients who were treated in Jiujiang NO.1 People's Hospital from March 2021 to March 2024 were divided into observation group and control group by the random number table method,with 48 cases in each group.The control group was treated with modified quadruple sequential therapy,and the observation group was treated with Moluodan on the basis of the control group.The clinical efficacy after 14 days of treatment and Hp negative conversion rate after 1 month of treatment were recorded.The levels of inflammatory factors and serum indexes before and after treatment were counted.Adverse reactions during treatment were recorded.Result:The clinical efficacy of the observation group was better than that of the control group,the difference was statistically significant(P<0.05).After treatment,the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C reactive protein(CRP)in the observation group were lower than those before treatment and those in the control group,the differences were statistically significant(P<0.05).The levels of pepsinogenⅠ(PGⅠ),gastrin(GAS)in the observation group were higher than those before treatment and those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the level of pepsinogenⅡ(PGⅡ)between the two groups(P>0.05).One month after treatment,38 cases of Hp in the observation group turned negative,with a negative conversion rate of 79.17%;a total of 29 cases in the control group were Hp negative,and the negative conversion rate was 60.42%,the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Moluodan combined with modified quadruple sequential therapy is effective in the trea

关 键 词：改良四联序贯疗法 摩罗丹 炎症因子 幽门螺杆菌 

分 类 号：R573.3[医药卫生—消化系统]