CYP2C19、ApoE基因多态性检测指导用药对急性脑梗死患者疗效及认知功能的影响  

Effects of CYP2C19 and ApoE Gene Polymorphism Detection on Guiding Medication on Therapeutic Effect and Cognitive Function in Patients with Acute Cerebral Infarction

作　　者：黄建锋 易飞[1] 张露娇 钟优优 HUANG Jianfeng;YI Fei;ZHANG Lujiao;ZHONG Youyou(Department of Neurology,Pingxiang People's Hospital,Pingxiang 337000,China;不详)

机构地区：[1]萍乡市人民医院神经内科,江西萍乡337000

出　　处：《中国医学创新》2025年第12期77-80,共4页Medical Innovation of China

基　　金：萍乡市科技计划项目(2023PY021)。

摘　　要：目的:观察细胞色素P450家族成员2C19(CYP2C19)、载脂蛋白E(ApoE)基因多态性检测指导用药对急性脑梗死(ACI)患者疗效及认知功能的影响。方法:选取2022年9月—2024年2月萍乡市人民医院收治的80例ACI患者,依据随机数字表法分为两组,各40例。对照组予以常规治疗,试验组予以CYP2C19、ApoE基因多态性检测指导用药。比较两组治疗前后血脂指标[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及总胆固醇(TC)]、蒙特利尔认知评估量表(MoCA)、改良Rankin量表(MRS)及美国国立卫生研究院卒中量表(NIHSS)评分,以及疗效及不良反应。结果:试验组总有效率高于对照组,差异有统计学意义(P<0.05);试验组治疗后LDL-C、TC均低于对照组,HDL-C高于对照组,差异均有统计学意义(P<0.05);试验组治疗后MoCA评分高于对照组,MRS、NIHSS评分均低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:CYP2C19、ApoE基因多态性检测指导用药有利于更好地改善ACI患者血脂水平及认知功能,提高临床疗效。Objective:To observe the effects of cytochrome P4502C19(CYP2C19)and apolipoprotein E(ApoE)gene polymorphism detection on guiding medication on therapeutic effect and cognitive function in patients with acute cerebral infarction(ACI).Method:A total of 80 ACI patients admitted to Pingxiang People's Hospital from September 2022 to February 2024 were selected and divided into two groups according to random number table method,with 40 cases in each group.The control group was given routine treatment,and the experimental group was given CYP2C19 and ApoE gene polymorphism detection to guide medication.Blood lipid indexes[low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and total cholesterol(TC)],Montreal cognitive assessment(MoCA),modified Rankin scale(MRS)and national institutes of health stroke scale(NIHSS)scores and efficacy and adverse reactions were compared between the two groups before and after treatment.Result:The total effective rate of experimental group was higher than that of control group,the difference was statistically significant(P<0.05).After treatment,LDL-C and TC of experimental group were lower than those of control group,and HDL-C was higher than that of control group,the differences were statistically significant(P<0.05).After treatment,MoCA score of experimental group was higher than that of control group,MRS and NIHSS scores were lower than those of control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:CYP2C19 and ApoE gene polymorphism detection to guide medication is beneficial to better improve the blood lipid levels and cognitive function of ACI patients,and improve the clinical efficacy.

关 键 词：急性脑梗死 细胞色素P450家族成员2C19 载脂蛋白E 基因多态性 认知功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]