胃功能三项指标、CA72-4在Hp阳性体检者胃部病变筛查中的应用价值  

Application Value of Three Indexes of Gastric Function and CA72-4 in the Screening of Gastric Lesions in Hp Positive Physical Examination Subjects

作　　者：姚芳斌 李苹 邓世华[1] 涂思佳 YAO Fangbin;LI Ping;DENG Shihua;TU Sijia(Department of Clinical Laboratory,the First People's Hospital of Fuzhou,Fuzhou 344000,China;不详)

机构地区：[1]抚州市第一人民医院检验科,江西抚州344000

出　　处：《中国医学创新》2025年第12期115-118,共4页Medical Innovation of China

基　　金：抚州市社会发展指导性科技计划项目(抚科社字(2023)7号第13号)。

摘　　要：目的:探究胃功能三项指标、糖类抗原72-4(CA72-4)在幽门螺杆菌(Hp)阳性体检者胃部病变筛查中的应用价值。方法:选取2023年3月—2024年3月于抚州市第一人民医院行胃镜检查的130例体检者作为研究对象。入组者均进行Hp检查,根据Hp检查结果将患者分为观察组(n=60,Hp阳性)与对照组(n=70,Hp阴性),将观察组中的患者按照是否存在胃部病变分为胃部疾病组(n=20)与非胃部疾病组(n=40)。比较观察组与对照组、胃部疾病组与非胃部疾病组胃泌素-17(G-17)、胃蛋白酶原(PG)Ⅰ、PGⅡ及CA72-4水平。采用Pearson相关性分析探究Hp阳性与胃功能三项指标、CA72-4的相关性,并绘制受试者操作特征(ROC)曲线分析胃功能三项指标、CA72-4对Hp阳性者胃部病变的诊断效能。结果:观察组G-17、CA72-4、PGⅡ均高于对照组,PGⅠ低于对照组(P<0.05)。胃部疾病组G-17、CA72-4均高于非胃部疾病组,PGⅠ低于非胃部疾病组(P<0.05);两组PGⅡ比较,差异无统计学意义(P>0.05)。Pearson相关性分析结果显示:Hp阳性与G-17、CA72-4、PGⅡ均呈正相关,与PGⅠ呈负相关(P<0.05)。G-17、PGⅠ及CA72-4联合诊断胃部病变的AUC为0.961,敏感度为90.00%,特异度为97.50%(P<0.05)。结论:Hp阳性与胃功能三项指标及CA72-4存在相关性,G-17、PGⅠ及CA72-4联合诊断Hp阳性者胃部病变有良好的效能。Objective:To investigate the application value of three indexes of gastric function and carbohydrate antigen 72-4(CA72-4)in the screening of gastric lesions in Helicobacter pylori(Hp)positive physical examination subjects.Method:A total of 130 patients who underwent gastroscopy in the First People's Hospital of Fuzhou from March 2023 to March 2024 were selected as the study objects.Hp examination was performed on all enrolled patients.Patients were divided into observation group(n=60,Hp positive)and control group(n=70,Hp negative)according to the Hp examination results.Patients in observation group were divided into gastric disease group(n=20)and non-gastric disease group(n=40)according to the presence of gastric lesions.The levels of gastrin-17(G-17),pepsinogen(PG)Ⅰ,PGⅡand CA72-4 were compared between the observation group and the control group,and between the gastric disease group and the non-gastric disease group.Pearson correlation analysis was used to explore the correlation between Hp positive and three indexes of gastric function and CA72-4,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of three indexes of gastric function and CA72-4 in HP positive subjects with gastric lesions.Result:G-17,CA72-4 and PGⅡin observation group were higher than those in control group,PGⅠwas lower than that in control group(P<0.05).G-17 and CA72-4 in gastric disease group were higher than those in non-gastric disease group,and PGⅠwas lower than that in nongastric disease group(P<0.05).There was no significant difference in PGⅡbetween the two groups(P>0.05).Pearson correlation analysis showed that Hp positive was positively correlated with G-17,CA72-4 and PGⅡ,and negatively correlated with PGⅠ(P<0.05).The area under the curve(AUC)of the combined diagnosis of G-17,PGⅠand CA72-4 was 0.961,the sensitivity was 90.00%,and the specificity was 97.50%(P<0.05).Conclusion:There is a correlation between Hp positive and three indexes of gastric function and CA72-4.The combinati

关 键 词：胃部病变 幽门螺杆菌 胃泌素-17 糖类抗原72-4 

分 类 号：R573[医药卫生—消化系统]