吡柔比星染色定位在非肌层浸润性膀胱癌手术治疗中的应用  

Application of Pirarubicin Staining Localization in the Surgical Treatment of Non-muscle-invasive Bladder Cancer

作　　者：陈秀祥 刘宇 徐建 CHEN Xiuxiang;LIU Yu;XU Jian(Department of Urology,Bijie Traditional Chinese Medicine Hospital,Bijie 551700,China;不详)

机构地区：[1]毕节市中医医院泌尿外科,贵州毕节551700

出　　处：《中国医学创新》2025年第12期154-158,共5页Medical Innovation of China

摘　　要：目的:分析吡柔比星(THP)染色定位在非肌层浸润性膀胱癌(NMIBC)手术治疗中的应用效果。方法:回顾性分析毕节市中医医院泌尿外科2022年1月—2023年7月收治的83例NMIBC患者的临床资料。按不同治疗方法分为两组,对照组(n=40)采用经尿道膀胱肿瘤电切术治疗,观察组(n=43)于术前30 min经膀胱灌注THP进行染色定位,随后行经尿道膀胱肿瘤电切术。对比两组手术情况、肿瘤标志物水平、分泌型调控因子水平、肿瘤复发及进展情况。结果:两组手术时间、术中失血量、术后住院时间比较,差异均无统计学意义(P>0.05)。观察组术后4周肿瘤标志物水平、分泌型调控因子水平均低于对照组,差异均有统计学意义(P<0.05)。两组术后并发症发生率、肿瘤进展率比较,差异均无统计学意义(P>0.05)。观察组肿瘤复发率为4.65%,低于对照组的25.00%,差异有统计学意义(P<0.05)。结论:NMIBC患者在经尿道膀胱肿瘤电切术前进行THP染色定位,可降低肿瘤标志物水平和肿瘤复发率。Objective:To analyze the application effect of Pirarubicin(THP)staining localization in the surgical treatment of non-muscle-invasive bladder cancer(NMIBC).Method:The clinical data of 83 NMIBC patients admitted to the Department of Urology,Bijie Traditional Chinese Medicine Hospital from January 2022 to July 2023 were retrospectively analyzed.They were divided into two groups according to different treatment methods.The control group(n=40)was treated with transurethral resection of bladder tumor,and the observation group(n=43)underwent THP staining localization by irrigation of bladder 30 min before surgery,and then transurethral resection of bladder tumor was performed.The operation status,tumor markers levels,secretory regulatory factors levels,tumor recurrence and progression were compared between the two groups.Result:There were no significant differences in operation time,intraoperative blood loss and postoperative hospital stay between the two groups(P>0.05).The levels of tumor markers and secretory regulatory factors in the observation group 4 weeks after surgery were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in the incidence of postoperative complications and the rate of tumor progression between the two groups(P>0.05).The recurrence rate of tumor in the observation group was 4.65%,which was lower than 25.00%in the control group,the difference was statistically significant(P<0.05).Conclusion:THP staining localization before transurethral resection of bladder tumor in NMIBC patients can reduce the levels of tumor markers and tumor recurrence rate.

关 键 词：经尿道膀胱肿瘤电切术 吡柔比星 非肌层浸润性膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤]