失眠障碍过度觉醒的功能神经影像学证据  

Functional Neuroimaging Evidence for Hyperarousal in Insomnia Disorder

作　　者：龙锦浩 林强隆 刘俊彬 田军章 LONG Jinhao;LIN Qianglong;LIU Junbin;TIAN Junzhang(Department of Nuclear Medicine,the Affiliated Guangdong Second Provincial General Hospital of Jinan University,Guangzhou 510317,China;不详)

机构地区：[1]暨南大学附属广东省第二人民医院核医学科,广东广州510317 [2]南方医科大学第二临床医学院,广东广州510260

出　　处：《中国医学创新》2025年第12期174-179,共6页Medical Innovation of China

摘　　要：失眠障碍(ID)是最普遍的睡眠障碍,严重危害人们的生活质量与身心健康。其发病机制尚无统一定论,过度觉醒是目前解释ID发病机制的主要理论,神经影像学的发展使其能在功能水平上研究大脑机制。本综述旨在通过整合现有的功能神经影像学研究来阐明ID患者在功能、代谢方面过度觉醒的证据。尽管结果不尽相同,但大部分表明ID患者经历了一种高度兴奋的状态,这些发现支持过度觉醒在ID病理生理学中扮演重要角色。未来应通过纵向研究来阐明整个疾病过程中过度觉醒的机制,推进神经影像学在ID诊断和预后评估中的应用。Insomnia disorder(ID)is the most common sleep disorder,which seriously endangers people's quality of life and physical and mental health.There is no unified conclusion on its pathogenesis,and hyperarousal is the main theory to explain the pathogenesis of ID at present.The development of neuroimaging enables it to study the brain mechanism at the functional level.This review aims to clarify the evidence of hyperarousal in function and metabolism of ID patients by integrating the existing functional neuroimaging studies.Although the results are different,most of them show that ID patients have experienced a state of high excitement,and these findings support that hyperarousal plays a key role in the pathophysiology of ID.In the future,we should clarify the mechanism of hyperarousal in the whole disease process through longitudinal research and promote the application of neuroimaging in ID diagnosis and prognosis evaluation.

关 键 词：失眠障碍 过度觉醒 功能神经影像学 

分 类 号：R749.7[医药卫生—神经病学与精神病学]