运动区低频重复经颅磁刺激联合盐酸氟西汀治疗强迫障碍的效果与安全性  

Effect and Safety of Low-frequency Repetitive Transcranial Magnetic Stimulation in Motor Area Combined with Fluoxetine Hydrochloride in the Treatment of Obsessive-compulsive Disorder

作　　者：李航 安敏杰 LI Hang;AN Minjie(Beijing Daxing District Xinkang Hospital,Beijing 102600,China;不详)

机构地区：[1]北京市大兴区心康医院,北京102600

出　　处：《中外医学研究》2025年第10期20-24,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察强迫障碍患者应用运动区低频重复经颅磁刺激(LF-rTMS)、盐酸氟西汀联合治疗的临床效果。方法:回顾性分析2022年6月—2023年6月北京市大兴区心康医院收治的100例强迫障碍患者的临床资料,按治疗方式不同分为药物组(药物治疗,n=40)与联合组(药物治疗联合LF-rTMS治疗,n=60)。比较两组临床疗效、强迫症状[耶鲁布朗强迫症量表(Y-BOCS)]、焦虑抑郁症状[汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)]、生活质量[健康调查简表(SF-36)]及安全性。结果:联合组临床总有效率高于药物组,差异有统计学意义(P<0.05);治疗1个月、治疗后,两组Y-BOCS评分较治疗前降低,且联合组治疗后Y-BOCS评分低于药物组,差异有统计学意义(P<0.05);治疗后,两组HAMD评分、HAMA评分较治疗前降低,且联合组低于药物组,差异有统计学意义(P<0.05);治疗后,两组生理功能(PF)、社会功能(SF)、情感职能(RE)、总体健康(GH)评分较治疗前升高,且联合组高于药物组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:LF-rTMS联合盐酸氟西汀治疗强迫障碍患者可有效提高临床效果,改善强迫、焦虑、抑郁症状,提高生活质量,且安全性良好。Objective:To observe the clinical effect of low-frequency repetitive transcranial magnetic stimulation(LF-rTMS)in motor area combined with Fluoxetine Hydrochloride in patients with obsessive-compulsive disorder.Method:The clinical data of 100 patients with obsessive-compulsive disorder who admitted to Beijing Daxing District Xinkang Hospital from June 2022 to June 2023 were retrospectively analyzed,they were divided into the drug group(drug treatment,n=40)and the combined group(drug treatment combined with LF-rTMS treatment,n=60)according to different treatment methods.The clinical efficacy,obsessive-compulsive symptoms[Yale-Brown obsessive compulsive scale(Y-BOCS)],anxiety and depression symptoms[Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA)],quality of life[the MOS item short form health survey(SF-36)]and safety were compared between two groups.Result:The clinical total effective rate of the combined group was higher than that of the drug group,the difference was statistically significant(P<0.05);After 1 month of treatment and after treatment,the Y-BOCS scores of two groups were lower than those before treatment,and the Y-BOCS score after treatment in the combined group were lower than those in the drug group,the differences were statistically significant(P<0.05);after treatment,the HAMD scores and HAMA scores of two groups were lower than those before treatment,and those in the combined group were lower than those in the drug group,the differences were statistically significant(P<0.05);after treatment,the scores of physiological function(PF),social function(SF),emotional function(RE)and general health(GH)in two groups were higher than those before treatment,and those in the combined group were higher than those in the drug group,the differences were statistically significant(P<0.05);there were no significant differences in the incidence of adverse reactions between two groups(P>0.05).Conclusion:LF-rTMS combined with Fluoxetine Hydrochloride in the treatment of patients with obsessive-compulsive

关 键 词：强迫障碍 运动区低频重复经颅磁刺激 盐酸氟西汀 临床疗效 安全性 

分 类 号：R749.7[医药卫生—神经病学与精神病学]