血栓弹力图和传统凝血功能实验检测对高血压性脑出血患者再出血风险的评估作用  

Evaluation of Thromboelastography and Conventional Coagulation Tests Detection on Rebleeding Risk in Patients with Hypertensive Cerebral Hemorrhage

作　　者：杨海韵 杨慧 YANG Haiyun;YANG Hui(Jingzhou Third People's Hospital,Jingzhou 434000,China;不详)

机构地区：[1]荆州市第三人民医院,湖北荆州434000

出　　处：《中外医学研究》2025年第10期64-67,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨血栓弹力图(TEG)、传统凝血功能实验(conventional coagulation tests,CCTs)检测对高血压性脑出血患者再出血风险的评估作用。方法:选取2021年1月-2023年12月荆州市第三人民医院收治的106例高血压性脑出血患者(观察组)及未出现脑出血的90例高血压患者(对照组)的临床资料。所有患者均进行TEG、CCTs检测。并按照治疗后60 min脑出血有无复发将观察组分为出血组(27例)、未出血组(79例)。对比观察组与对照组,以及出血组与未出血组的TEG和CCTs指标。TEG参数包含凝血启动时间(R)、K时间(K)、α角(Angle)、血小板聚集功能(MA)、凝血综合指数(CI)、纤溶指数(LY30);CCTs指标包含凝血酶原时间(PT)、国际标准化比值(INR)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原浓度(FIB)、D-二聚体(D-D)、血小板计数(PLT)。结果:观察组R、K、LY30、PT、INR、APTT、TT、D-D均高于对照组,Angle、MA、CI、FIB、PLT均低于对照组,差异有统计学意义(P<0.05)。出血组R、K、LY30、PT、INR、APTT、TT、D-D均高于未出血组,Angle、MA、CI、FIB、PLT均低于未出血组,差异有统计学意义(P<0.05)。结论:TEG、CCTs检测对高血压性脑出血患者具有一定检测价值,可有效评估再出血风险。Objective:To evaluate the thromboelastography(TEG)and conventional coagulation tests(CCTs)detection on rebleeding risk in patients with hypertensive cerebral hemorrhage.Method:The clinical data of 106 patients with hypertensive intracerebral hemorrhage(as observation group)and 90 patients without intracerebral hemorrhage(as control group)admitted to Jingzhou Third People's Hospital from January 2021 to December 2023 were selected.All patients underwent TEG and CCTs detection.According to the recurrence of cerebral hemorrhage 60 minutes after treatment,the observation group was divided into bleeding group(27 cases)and non-bleeding group(79 cases).The TEG and CCTs indexes were compared between the observation group and the control group,and between the bleeding group and the non-bleeding group.TEG parameters included coagulation initiation time(R),K time(K),αAngle(Angle),platelet aggregation function(MA),coagulation composite index(CI)and fibrinolytic index(LY30).CCTs measures included prothrombin time(PT),international normalized ratio(INR),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen concentration(FIB),D-dimer(D-D),and platelet count(PLT).Result:R,K,LY30,PT,INR,APTT,TT,and D-D were in the observation group were higher than those in the control group,and Angle,MA,CI,FIB and PLT were lower than those in the control group,the differences were statistically significant(P<0.05).R,K,LY30,PT,INR,APTT,TT,and D-D in the bleeding group were higher than those in the non-bleeding group,and Angle,MA,CI,FIB and PLT were lower than those in the non-bleeding group,the differences were statistically significant(P<0.05).Conclusion:The implementation of TEG and CCTs detection in patients with hypertensive cerebral hemorrhage can effectively evaluate the severity of the disease and the prognosis,and the combined test is more effective.

关 键 词：高血压 脑出血 血栓弹力图 传统凝血功能检验 预后评估 

分 类 号：R743.34[医药卫生—神经病学与精神病学]