眼表鳞状细胞肿瘤诊断及治疗新进展  

Advances in the diagnosis and treatment of ocular surface squamous neoplasia

作　　者：耿雯 谢华桃 王家松 张明昌[1] Geng Wen;Xie Huatao;Wang Jiasong;Zhang Mingchang(Department of Ophthalmology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China)

机构地区：[1]华中科技大学同济医学院附属协和医院眼科,湖北省武汉市430022

出　　处：《国际眼科杂志》2025年第5期743-748,共6页International Eye Science

基　　金：国家自然科学基金面上项目(No.82070934,82171025)。

摘　　要：眼表鳞状细胞肿瘤(OSSN)是由角结膜上皮异常增生而形成的一系列病态实体瘤,是成年人最常见的眼表肿瘤之一。近二十年来,对于眼表鳞状细胞肿瘤的治疗逐步从手术治疗向局部药物治疗发生转变。干扰素、5-氟尿嘧啶和丝裂霉素是临床治疗该疾病最常用的局部药物。文章总结了眼表鳞状细胞肿瘤的诊断及各种局部化疗治疗方案,并强调高分辨率光学相干断层扫描技术(HR-OCT)在该疾病诊治中的潜在作用。Ocular surface squamous neoplasia(OSSN)is a series of pathological solid tumors formed by dysplasia of keratoconjunctival epithelium,which is one of the most common ocular surface tumors in adults.In the past two decades,the treatment of OSSN has gradually changed from surgical resection to topical chemotherapy.Interferons,5-fluorouracil and mitomycin are the most commonly used topical agents for the clinical treatment of this disease.This paper summarizes the diagnosis of OSSN and various local chemotherapy treatment options,highlights the potential role of high-resolution optical coherence tomography(HR-OCT)technology in the diagnosis and treatment of this disease.

关 键 词：眼表鳞状细胞肿瘤 局部药物治疗 高分辨率光学相干断层扫描 

分 类 号：R739.7[医药卫生—肿瘤]