代谢组学在年龄相关性黄斑变性中的研究进展  

Research progress of metabolomics in age-related macular degeneration

作　　者：王烽 蓝诚红[1] 刘毅玲 邵毅 Wang Feng;Lan Chenghong;Liu Yiling;Shao Yi(Department of Ophthalmology,Meizhou People's Hospital,Meizhou 514000,Guangdong Province,China;Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]广东省梅州市人民医院眼科,514000 [2]上海交通大学医学院附属第一人民医院眼科中心,上海市200080

出　　处：《国际眼科杂志》2025年第5期760-764,共5页International Eye Science

基　　金：国家自然科学基金项目(No.82160195);广东省梅州市医药卫生科研立项课题(No.2023-B-32);广东省梅州市人民医院科研培育项目(No.PY-C2021060)。

摘　　要：年龄相关性黄斑变性(ARMD)是老年人常见的多因素疾病,可能导致不可逆的视力丧失;然而,ARMD的发病机制尚不清楚。代谢组学是一种相对较新的“组学”技术,它可以提供有关生物系统中低分子量代谢物的定性和定量信息,从而揭示细胞或组织样品在特定时间点的生理或病理状态。近年来,越来越多的证据表明代谢功能障碍在ARMD的发展和进展中起着重要作用。代谢途径失调涉及脂质代谢、核苷酸代谢、氨基酸代谢和能量代谢,这些可能在ARMD的发生发展中发挥重要作用。视网膜是人体代谢最活跃的组织之一,因此使用代谢组学技术来测量ARMD的分子变化将进一步增强对发病机制的理解,这将为ARMD的预防和治疗提供重要的见解。文章就代谢组学在ARMD中的应用作一综述。Age-related macular degeneration(ARMD)is a common multifactorial disease among the elderly,which may lead to irreversible vision loss;however,the pathogenesis of ARMD is still unclear.Metabolomics is a relatively new“omics”technique that can provide qualitative and quantitative information about low molecular weight metabolites that make up biological systems,thereby revealing the physiological or pathological state of cell or tissue samples at specific time points.In recent years,increasing evidence suggests that metabolic dysfunction plays an important role in the development and progression of ARMD.Metabolic pathway dysregulation involves lipid metabolism,nucleotide metabolism,amino acid metabolism,and energy metabolism,which may play important roles in the occurrence and development of ARMD.The retina is one of the most metabolically active tissues in the human body,so using metabolomics techniques to measure molecular changes in ARMD will further enhance our understanding of the pathogenesis.This will provide important insights for the prevention and treatment of ARMD,This article reviews the application of metabolomics in ARMD.

关 键 词：年龄相关性黄斑变性 代谢组学 生物标志物 代谢途径 

分 类 号：R774.5[医药卫生—眼科]