3%地夸磷索钠滴眼液治疗白内障术后干眼的效果及对泪膜稳定性的影响  

Efficacy of 3%diquafosol sodium ophthalmic solution in dry eye syndrome after cataract surgery and its impact on tear film stability

作　　者：李秀婷 权艳 王丽丽[1] Li Xiuting;Quan Yan;Wang Lili(Department of Ophthalmology,Xi'an Aier Eye Hospital,Northwest University,Xi'an 710000,Shaanxi Province,China)

机构地区：[1]西北大学附属西安爱尔眼科医院,陕西省西安市710000

出　　处：《国际眼科杂志》2025年第5期854-857,共4页International Eye Science

摘　　要：目的:评估3%地夸磷索钠滴眼液治疗白内障手术后干眼的效果及其对泪膜稳定性的影响。方法:前瞻性临床研究。选取于2021-01/2024-01在西北大学附属西安爱尔眼科医院进行白内障超声乳化手术的患者124例124眼,每例患者仅纳入1眼进行统计分析,如果患者双眼均符合纳入标准,则采用随机数字表法选择1眼纳入研究,使用随机数字表法将患者分为研究组62例62眼、对照组62例62眼。研究组使用3%地夸磷索钠滴眼液进行治疗,4次/天,持续1 mo;对照组使用玻璃酸钠滴眼液进行治疗,4次/天,持续1 mo。比较两组的临床疗效、泪膜破裂时间(BUT)、基础泪液分泌试验(SⅠt)、角膜荧光素染色评分(FL)、泪液中炎症因子[白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)]水平和不良反应。结果:研究组治疗有效率为93.5%,对照组治疗有效率87.1%,两组间比较无差异(P>0.05)。研究组患者治疗1 mo后BUT、SⅠt显著高于对照组,FL评分、泪液中炎症因子水平显著低于对照组(均P<0.05)。两组不良反应的发生率无差异(P=0.198)。结论:3%地夸磷索钠滴眼液显著改善白内障术后干眼患者的泪液分泌和泪膜稳定性,有效缓解干眼症状,是一种安全有效的治疗方法。AIM:To evaluate the efficacy of 3%diquafosol sodium ophthalmic solution in treating dry eye syndrome following cataract surgery and its impact on tear film stability.METHODS:This prospective clinical study was conducted at Xi’an Aier Eye Hospital,Northwest University from January 2021 to January 2024.A total of 124 patients(124 eyes)who underwent cataract phacoemulsification were enrolled and randomly assigned to either the study group(62 cases,62 eyes)or the control group(62 cases,62 eyes)using a random number table.The study group received 3%diquafosol sodium ophthalmic solution four times daily for 1 mo,while the control group was treated with sodium hyaluronate eye drops four times daily for 1 mo.Clinical efficacy,tear film breakup time(BUT),Schirmer I test(SⅠt),corneal fluorescein staining(FL)score,inflammatory factors[interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)]levels in tears,and adverse reactions were compared between the two groups.RESULTS:After treatment,the effective rate was 93.5%in the study group and 87.1%in the control group,with no significant difference between the two groups(P>0.05).The study group showed significantly higher BUT,SⅠt values compared to the control group,while FL score,and inflammatory factor levels in tears were significantly lower at 1 mo after treatment(all P<0.05).The incidence of adverse reactions did not differ significantly between the two groups(P=0.198).CONCLUSION:The 3%diquafosol sodium ophthalmic solution significantly improves tear secretion and tear film stability in patients with dry eye syndrome after cataract surgery,effectively alleviating dry eye symptoms.It is a safe and effective treatment method.

关 键 词：地夸磷索钠滴眼液 白内障手术 干眼 泪膜稳定性 

分 类 号：R779.6[医药卫生—眼科]