18F-FDG PET/CT代谢参数在单发骨转移非小细胞肺癌患者中的预后价值  

The Prognostic Value of 18 F-FDG PET/CT Metabolic Parameters in Non-small Cell Lung Cancer Patients with Synchronous Solitary Bone Metastasis

作　　者：夏前之 咸娴 何超 徐峰 XIA Qianzhi;XIAN Xian;HE Chao;XU Feng(Suqian Clinical College,Xuzhou Medical University,Suqian 223800,China;Suqian Hospital,Jiangsu Provincial People’s Hospital,Suqian 223800,China;The First Affiliated Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]徐州医科大学宿迁临床学院,江苏宿迁223800 [2]江苏省人民医院宿迁医院,江苏宿迁223800 [3]苏州大学附属第一医院,江苏苏州215006

出　　处：《标记免疫分析与临床》2025年第3期532-536,567,共6页Labeled Immunoassays and Clinical Medicine

基　　金：宿迁市第一人民医院科研专项项目(编号:SY202302)。

摘　　要：目的分析18 F-FDG PET/CT全身显像在单发骨转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)患者中的预后价值。方法回顾性分析2019年1月至2024年5月就诊于苏州大学附属第一医院的64例单发骨转移NSCLC患者的临床资料。纳入代谢参数、临床病理特征等相关因素,采用Kaplan-Meier生存分析和Cox回归模型确定各因素与总生存期(overall survival,OS)之间的关系。结果所有单发骨转移患者中,胸部骨(40.63%)和中轴骨(37.50%)是最常见的转移部位。多因素生存分析表明,肿瘤最大直径(HR=3.299;95%CI:1.734~6.278,P<0.001)、淋巴结转移(HR=0.094;95%CI:0.013~0.712,P=0.022)、糖酵解总量(total lesion glycolysis,TLG)(HR=2.325;95%CI:1.057~5.111,P=0.036)是单发骨转移非小细胞肺癌患者的独立预后因素。结论肿瘤大小、淋巴结转移和原发灶TLG是单发骨转移非小细胞肺癌患者的独立预后因素,具有良好的生存预测价值,可用于这类患者的风险分层。Objective This study aimed to analyze and identify prognostic factors in non-small cell lung cancer(NSCLC)patients with synchronous solitary bone metastasis.Methods The clinical data of 64 NSCLC patients admitted to the First Affiliated Hospital of Soochow University from January,2019 to May,2024 were retrospectively analyzed.We incorporated relevant factors,such as metabolic parameters and clinical pathological characteristics into the analysis.Kaplan-Meier survival analysis and Cox regression models were applied to evaluate the relationship between these factors and overall survival(OS).Results Thoracic bone(40.63%)and midshaft bone(37.50%)were the most common sites of metastasis in all patients with synchronous solitary bone metastasis.Multifactorial survival analysis showed that maximum tumor diameter(HR=3.299,95%CI:1.734-6.278,P<0.001),lymph node metastasis(HR=0.094,95%CI:0.013-0.712,P=0.022),total lesion glycolysis(TLG)(HR=2.325,95%CI:1.057-5.111,P=0.036)were independent prognostic factors in patients with non-small cell lung cancer with synchronous solitary bone metastasis.Conclusion Our results suggest that tumor size,lymph node metastasis,and TLG are independent prognostic factors in patients with non-small cell lung cancer with solitary bone metastasis,which show strong survival predictive values and can be used for risk stratification of this type of patients.

关 键 词：非小细胞癌 单发骨转移 PET/CT 代谢参数 

分 类 号：R734.2[医药卫生—肿瘤]