牙周炎超重肥胖人群免疫炎症特点及与内脏脂肪关系研究  

Characteristics of immune inflammation in overweight and obese people with periodontitis and its relationship with visceral fat area

作　　者：丁文萃[1] 肖遵胜[2] 王丽晖 贾惠雯 靳艳艳 李新胜[1] DING Wen-cui;XIAO Zun-sheng;WANG Li-hui;JIA Hui-wen;JIN Yan-yan;LI Xin-sheng(Department of Endocrinology and Diabetes,Cangzhou Central Hospital,Hebei Cangzhou 061001,China;Department of Stomatology,Cangzhou Central Hospital,Hebei Cangzhou 061001,China)

机构地区：[1]沧州市中心医院内分泌糖尿病一科,河北沧州061001 [2]沧州市中心医院口腔门诊,河北沧州061001

出　　处：《临床口腔医学杂志》2025年第3期160-165,共6页Journal of Clinical Stomatology

基　　金：沧州市重点研发计划自筹项目(项目编号:222106007)。

摘　　要：目的:探讨伴有牙周炎超重肥胖人群免疫炎症特点及其与内脏脂肪面积(visceral fat area,VFA)的关系。方法:选择2022年1月~2024年1月我院收治的206例牙周炎患者为研究对象,根据身体质量指数(body mass index,BMI)将患者分为正常组,超重组,肥胖组。采用免疫速率散射比浊法、流式细胞仪和酶联免疫吸附法测定免疫炎症因子;采用DBA-550生物电阻抗测量法测量VFA;采用Logistic回归分析免疫炎症因子与VFA之间的关系;使用Logistic回归模型对危险因素交互作用进行分析。结果:三组患者的免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白A(IgA)、白介素-4(interleukin-4,IL-4)、IL-17、VFA比较均差异显著(P<0.05)。肥胖组IgG、IgA、IL-4、IL-17、CD4^(+)、CD4^(+)/CD8^(+)、VFA水平高于正常组、超重组(P<0.05),CD8^(+)、IL-10水平低于正常组、超重组(P<0.05)。Logistic回归分析结果显示,VFA增加与IgA、IL-4独立相关(P<0.05),与IgG、IL-17无相关性(P>0.05)。牙周炎组与非牙周炎组的IgG、IgA、IgM、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、IL-4、IL-10、IL-17、VFA水平比较差异显著(P<0.05)。分层回归分析结果显示,IL-4和VFA对患牙周炎产生显著的负向影响关系(P<0.05)。相加交互模型显示,IL-4和VFA在牙周炎发病中存在显著的相加交互作用(P<0.05)。结论:牙周炎患者免疫炎症因子及VFA在不同BMI中有显著差异性,肥胖组牙周炎患者免疫炎症因子水平最高且VFA增加明显,高IL-4水平和超重同时存在时,患牙周炎风险大大增加。Objective:To investigate the characteristics of immune inflammation in overweight and obese people with periodontitis and its relationship with visceral fat area(VFA).Methods:A total of 206 patients with periodontitis admitted to our hospital from January 2022 to January 2024 were selected as the study subjects,and the patients were divided into normal group(BMI<25 kg/m~2,n=69),overweight group(25 kg/m~2≤BMI≤30 kg/m~2,n=80),and obesity group(BMI>30 kg/m~2,n=57).Immune inflammatory factors were measured using immune rate scattering turbidimetry,flow cytometry,and enzyme-linked immunosorbent assay.VFA was measured by DBA-550 bioelectrical impedance measurement.Logistic regression was used to analyze the relationship between immune inflammatory factors and VFA.Logistic regression model was used to analyze the interaction of risk factors.Results:There were significant differences in immunoglobulin G(IgG),IgA,interleukin-4(IL-4),IL-17,and VFA among the three groups of patients(P<0.05).The levels of IgG,IgA,IL-4,IL-17,CD4^(+),CD4^(+)/CD8^(+)and VFA in the obesity group were higher than those in the normal group and overweight group(P<0.05),and the levels of CD8^(+)and IL-10 were lower than those in the normal group and overweight group(P<0.05).Logistic regression analysis showed that an increase in VFA was independently correlated with IgA and IL-4(P<0.05),but not with IgG and IL-17(P>0.05).There were significant differences in IgG,IgA,IgM,CD4^(+),CD8^(+),CD4^(+)/CD8^(+),IL-4,IL-10,IL-17,and VFA levels between the periodontitis group and the non periodontitis group(P<0.05).Stratified regression analysis showed that IL-4 and VFA had a significant negative impact on periodontitis(P<0.05).The additive interaction model showed significant additive interaction between IL-4 and VFA in the pathogenesis of periodontitis(P<0.05).Conclusion:There were significant differences in the levels of immune inflammatory factors and VFA in periodontitis patients in the obesity group,and the risk of periodontitis was greatly increased

关 键 词：牙周炎 免疫炎症因子 内脏脂肪面积 身体质量指数 

分 类 号：R781.4[医药卫生—口腔医学]