姜黄三七贴联合吡柔比星治疗横纹肌肉瘤术后患儿及对水通道蛋白1、细胞外信号调节激酶及黏着斑激酶的影响  

Effect of Jianghuang Sanqi Paste Combined with Pirarubicin on Postoperative Children with Rhabdomyosarcoma and the Effect on Aquaporin 1,Extracellular Signal-regulated Kinase and Focal Adhesion Kinase

作　　者：于龙 马志 何睿 佘坤昊 毕立新 石珊珊 YU Long;MA Zhi;HE Rui;SHE Kunhao;BI Lixin;SHI Shanshan(Department of Pediatric Surgery,Affiliated Hongqi Hospital of Mudanjiang Medical University,Mudanjiang 157011,Heilongjiang,China;Digestive Endoscopy Center,Affiliated Hongqi Hospital of Mudanjiang Medical University,Mudanjiang 157011,Heilongjiang,China)

机构地区：[1]牡丹江医科大学附属红旗医院小儿外科,黑龙江牡丹江157011 [2]牡丹江医科大学附属红旗医院消化内镜中心,黑龙江牡丹江157011

出　　处：《世界复合医学(中英文)》2025年第2期15-19,共5页World Journal of Complex Medicine

基　　金：黑龙江省省属高等学校基本科研业务费科研项目(2022-KYYWF-0666)。

摘　　要：目的探讨姜黄三七贴联合吡柔比星治疗横纹肌肉瘤的疗效及对患儿水通道蛋白1(aquaporin 1,AQP1)、细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)及黏着斑激酶(focal adhesion kinase,FAK)的影响。方法选取2021年1月—2023年12月牡丹江医科大学附属红旗医院收治的94例横纹肌肉瘤术后患儿为研究对象,按治疗方法的不同分为观察组、对照组,各47例。对照组以吡柔比星治疗,观察组在对照组基础上联合姜黄三七贴治疗。对比两组临床疗效、肿瘤标志物、AQP1、ERK、FAK水平、不良反应发生率。结果观察组治疗总有效率为87.23%(41/47),高于对照组的70.21%(33/47),差异有统计学意义(χ^(2)=4.065,P<0.05)。治疗后,观察组肌红蛋白、波纹蛋白、肌球蛋白、AQP1、ERK、FAK水平均低于对照组,差异均有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论姜黄三七贴联合吡柔比星治疗横纹肌肉瘤的效果良好,能够降低肿瘤标志物水平,抑制患儿AQP1、ERK及FAK水平,治疗安全性良好。Objective To investigate the efficacy of Jianghuang Sanqi Paste combined with pirarubicin in the treatment of children with rhabdomyosarcoma and its effect on aquaporin 1(AQP1),extracellular signalregulated kinase(ERK)and focal adhesion kinase(FAK).Methods A total of 94 children with rhabdomyosarcoma treated in Affiliated Hongqi Hospital of Mudanjiang Medical University from January 2021 to December 2023 were selected as the research objects.According to the different treatment methods,they were divided into observation group and control group,with 47 cases in each group.The control group was treated with pirarubicin,and the observation group was treated with Jianghuang Sanqi Paste on the basis of the control group.The clinical efficacy,tumor marker,AQP1,ERK,FAK levels,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 87.23%(41/47),which was higher than 70.21% (33/47) in the control group , and the difference was statistically significant (x^(2)=4.065, P<0.05). After treatment, the levels of myoglobin, vimentin, myosin, AQP1, ERK and FAK in the observationgroup were lower than those in the control group, and the differences were statistically significant (all P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Jianghuang Sanqi Paste combined with pirarubicin is effective in the treatment of rhabdomyosarcoma.It can reduce the level of tumor markers, inhibit the levels of AQP1, ERK and FAK in children,and has good therapeutic safety.

关 键 词：横纹肌肉瘤 吡柔比星 姜黄三七贴 

分 类 号：R737.26[医药卫生—肿瘤]