氧化铁纳米颗粒在口腔感染性疾病防治中的研究进展  

Research progress on iron oxide nanoparticles in the prevention and treatment of oral infectious diseases

作　　者：覃涛 陈婧 程磊[1] QIN Tao;CHEN Jing;CHENG Lei(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,四川成都610041

出　　处：《牙体牙髓牙周病学杂志》2025年第3期180-186,共7页Chinese Journal of Conservative Dentistry

基　　金：国家自然科学基金面上项目(82071106);四川省自然科学基金青年项目(2024NSFSC1920)。

摘　　要：近年来,氧化铁纳米颗粒因其优异的性能受到了生物医学界的广泛关注。目前,为了更好治疗和预防口腔感染性疾病,学者们也开展了大量有关氧化铁纳米颗粒的研究,主要包括利用其过氧化物酶样活性防治龋病、牙髓根尖周病、牙周炎、种植体周围炎和口腔黏膜疾病等。本文回顾了氧化铁纳米颗粒应用于口腔感染性疾病防治的研究进展,以及目前主要的应用限制,以期为氧化铁纳米颗粒的临床应用转化提供研究思路。Recently,iron oxide nanoparticles have attracted extensive attention from the biomedical community due to their excellent properties.At present,researchers have conducted numerous studies on iron oxide nanoparticles to improve the treatment and prevention of oral infectious diseases,primarily utilizing their peroxidase-like activity to address caries,pulpitis,apical periodontitis,peri-implantitis and oral mucosal diseases.This paper reviews the research progress and main application limitations of iron oxide nanoparticles in the prevention and treatment of oral infectious diseases,aiming to provide insights for the clinical application and translation.

关 键 词：氧化铁纳米颗粒 口腔感染性疾病 龋病 牙髓根尖周病 牙周炎 种植体周炎 口腔黏膜疾病 

分 类 号：R781[医药卫生—口腔医学]