甲状腺癌术后妊娠患者母婴结局及影响因素分析  

Analysis of maternal-infant outcomes and influencing factors in postoperative pregnancy patients with thyroid cancer

作　　者：华知奋 董佳倩 季丹 彭婷 HUA Zhifen;DONG Jiaqian;JI Dan;PENG Ting(Department of Obstetrics,Changning Maternity&Infant Health Hospital,Shanghai 200040,China)

机构地区：[1]长宁区妇幼保健院产科,上海200040

出　　处：《癌症进展》2025年第7期817-819,828,共4页Oncology Progress

基　　金：上海市医学重点专科建设项目(ZK2019B02)。

摘　　要：目的探讨甲状腺癌术后妊娠患者母婴结局及影响因素。方法选取102例甲状腺癌术后妊娠患者,记录患者的母婴结局,比较母婴结局良好与母婴结局不良患者的临床特征。甲状腺癌术后妊娠患者母婴结局的影响因素采用多因素Logistic回归模型分析。结果102例甲状腺癌术后患者母婴情况,母婴结局不良20例,母婴结局良好82例,分别纳入母婴结局良好组和母婴结局不良组。母婴结局良好组与母婴结局不良组患者定期产检情况、妊娠情况、流产史、产前负性情绪情况、术后服用左甲状腺素钠片情况、TNM分期、淋巴结转移情况、游离甲状腺素水平比较,差异均有统计学意义(P﹤0.05)。多因素Logistic回归分析结果显示,术后服用左甲状腺素钠片是甲状腺癌术后妊娠患者母婴结局的保护因素(P﹤0.05),TNM分期为Ⅲ~Ⅳ期是甲状腺癌术后妊娠患者母婴结局的危险因素(P﹤0.05)。结论术后服用左甲状腺素钠片是甲状腺癌术后妊娠患者母婴结局的保护因素,TNM分期为Ⅲ~Ⅳ期是甲状腺癌术后妊娠患者母婴结局的危险因素。Objective To analyze the maternal-infant outcomes and influencing factors in postoperative pregnancy patients with thyroid cancer.Method A total of 102 postoperative pregnancy patients with thyroid cancer were selected,the maternal-infant outcomes were recorded,and the clinical characteristics of patients with good maternal-infant outcomes and patients with poor maternal-infant outcomes were compared.The influencing factors of maternal-infant outcomes in postoperative pregnancy patients with thyroid cancer were analyzed by Multivariate Logistic regression model.Result Among 102 postoperative pregnancy patients with thyroid cancer,20 cases had poor maternal-infant outcomes,and 82 cases had good maternal-infant outcomes,they were included in the poor maternal-infant outcome group and the good maternal-infant outcome group,respectively.There were statistically significant differences in regular prenatal check ups,pregnancy status,history of miscarriage,negative emotions before delivery,postoperative use of levothyroxine sodium tablets,TNM staging,lymph node metastasis,and free thyroxine levels between the good maternal-infant outcome group and the poor maternal-infant outcome group(P<0.05).Multivariate Logistic regression analysis showed that postoperative use of levothyroxine sodium tablets was protective factor for maternal-infant outcomes in postoperative pregnancy patients with thyroid cancer(P<0.05),and TNM stage III-IV was risk factor for maternal-infant outcomes in postoperative pregnancy patients with thyroid cancer(P<0.05).Conclusion Postoperative use of levothyroxine sodium tablets is protective factor for maternal-infant outcomes in postoperative pregnancy patients with thyroid cancer,and TNM stage III-IV is risk factor for maternal-infant outcomes in postoperative pregnancy patients with thyroid cancer.

关 键 词：甲状腺癌 妊娠 母婴结局 影响因素 

分 类 号：R736.1[医药卫生—肿瘤]