常规分割后缩野同步放化疗治疗鼻咽癌患者的临床疗效及对预后的影响  

Clinical efficacy of conventional fractionated reduced field concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma and its effect on prognosis

作　　者：刘花 廖鹏飞 陈维斌 梁小芳 LIU Hua;LIAO Pengfei;CHEN Weibin;LIANG Xiaofang(Department of Otolaryngology Head and Neck Surgery,Yichun People’s Hospital,Yichun 336000,Jiangxi,China;Department of Oncology,Yichun People’s Hospital,Yichun 336000,Jiangxi,China)

机构地区：[1]宜春市人民医院耳鼻咽喉头颈外科,江西宜春336000 [2]宜春市人民医院肿瘤科,江西宜春336000

出　　处：《癌症进展》2025年第7期829-832,共4页Oncology Progress

摘　　要：目的探讨常规分割后缩野同步放化疗治疗鼻咽癌(NPC)患者的临床疗效及对预后的影响。方法根据治疗方法的不同将40例NPC患者分为对照组(n=19,采取同步推量同步放化疗)和研究组(n=21,采取常规分割后缩野同步放化疗)。比较两组患者的临床疗效、不良反应发生情况及预后情况。结果两组患者治疗总有效率、1年无进展生存率、1年总生存率比较,差异均无统计学意义(P﹥0.05)。研究组患者3级及以上不良反应发生率为19.05%,低于对照组患者的52.63%,差异有统计学意义(P﹤0.05)。结论同步推量同步放化疗和常规分割后缩野同步放化疗均可使NPC患者获得较好的临床疗效和预后,而常规分割后缩野同步放化疗可减少不良反应。Objective To investigate the clinical efficacy of conventional fractionated reduced field concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma(NPC)and its effect on prognosis.Method According to different treatment methods,40 NPC patients were divided into control group(n=19,received simultaneous dose concurrent chemoradiotherapy)and study group(n=21,received conventional fractionated reduced field concurrent chemoradiotherapy).The clinical efficacy,adverse reactions and prognosis of the two groups were compared.Result There were no significant differences in the overall response rate,1-year progression-free survival rate and 1-year overall survival rate between the two groups(P>0.05).The incidence of grade 3 and above adverse reactions in the study group was 19.05%,lower than 52.63%in the control group,and the difference was statistically significant(P<0.05).Conclusion Both simultaneous dose concurrent chemoradiotherapy and conventional fractionated reduced field concurrent chemoradiotherapy can achieve better clinical efficacy and prognosis in NPC patients,while conventional fractionated reduced field concurrent chemoradiotherapy can reduce adverse reactions.

关 键 词：鼻咽癌 同步放化疗 常规分割 不良反应 预后 

分 类 号：R739.6[医药卫生—肿瘤]