术前细胞角质蛋白19片段抗原21-1、糖类抗原125水平与非小细胞肺癌手术患者远期预后的关系  

Relationship between preoperative levels of cyto-keratin 19 fragment antigen 21-1 and carbohydrate antigen 125 and long-term prognosis of patients with non-small cell lung cancer undergoing surgery

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作  者:高双双 周静 许玉丹 GAO Shuangshuang;ZHOU Jing;XU Yudan(Department of Medical Laboratory,Nanyang Chinese Medicine Hospital,Nanyang 473000,He’nan,China)

机构地区:[1]南阳市中医院医学检验科,河南南阳4730000

出  处:《癌症进展》2025年第7期844-846,863,共4页Oncology Progress

摘  要:目的探讨术前细胞角质蛋白19片段抗原21-1(CYFRA21-1)、糖类抗原125(CA125)水平与非小细胞肺癌(NSCLC)手术患者远期预后的关系。方法将90例NSCLC手术患者按预后情况分为预后不良组(19例)和预后良好组(71例)。比较两组患者临床特征和术前CYFRA21-1、CA125水平,分析NSCLC手术患者远期预后的影响因素。结果预后不良组与预后良好组患者各临床特征比较,差异均无统计学意义(P﹥0.05)。预后不良组患者CYFRA21-1、CA125水平均明显高于预后良好组,差异均有统计学意义(P﹤0.01)。Logistic回归分析结果显示,术前血清CYFRA21-1、CA125水平高均是NSCLC手术患者远期预后不良的危险因素(P﹤0.05)。结论术前血清CYFRA21-1、CA125水平高均是NSCLC手术患者远期预后不良的危险因素。Objective To observe the relationship between the preoperative levels of cyto-keratin 19 fragment antigen 21-1(CYFRA21-1)and carbohydrate antigen 125(CA125)and the long-term prognosis of patients with non-small cell lung cancer(NSCLC)undergoing surgery.Method A total of 90 patients with NSCLC were divided into poor prognosis group(19 cases)and good prognosis group(71 cases)according to prognosis.The clinical characteristics and preoperative CYFRA21-1 and CA125 levels of the two groups were compared,and the influencing factors of long-term prognosis of NSCLC patients undergoing surgery were analyzed.Result There were no significant differences in clinical characteristics between the poor prognosis group and the good prognosis group(P>0.05).The levels of CYFRA21-1 and CA125 in poor prognosis group were significantly higher than those in good prognosis group,and the differences were statistically significant(P<0.01).Logistic regression analysis showed that high levels of preoperative serum CYFRA21-1 and CA125 were risk factors for poor long-term prognosis of patients with NSCLC(P<0.05).Conclusion High preoperative serum CYFRA21-1 and CA125 levels are risk factors for poor long-term prognosis in patients with NSCLC after surgery.

关 键 词:非小细胞肺癌 细胞角质蛋白19片段抗原21-1 糖类抗原125 预后不良 

分 类 号:R734.2[医药卫生—肿瘤]

 

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