SMURF1:a promising target for colon cancer therapy  

作　　者：Xiufang Xiong Yongchao Zhao Yi Sun 

机构地区：[1]Cancer Institute of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310029,China [2]Department of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [3]Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou 310029,China

出　　处：《Protein & Cell》2025年第3期157-160,共4页蛋白质与细胞(英文版)

基　　金：supported by the National Key Research and Development Program of China(2022YFC3401500 to Y.Z.and Y.S.,2021YFA1101000 to Y.S.);the National Natural Science Foundation of China(32471300,92053117,and 81972591 to Y.Z.,92253203 and U22A20317 to Y.S.,81974429 and 82172898 to X.X.);the Natural Science Foundation of Zhejiang Province(LZ22H160003 to Y.Z.,LD22H300003 to Y.S.);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002 to Y.S.).

摘　　要：SMURF1(Smad ubiquitination regulatory factor 1),a HECT-type E3 ubiquitin ligase,plays pivotal regulatory roles in numerous biological processes,encompassing apoptosis,senescence,cell cycle progression,metastasis,and genomic stability,by targeting a variety of key signaling and regulatory proteins for ubiquitylation and proteasome degradation(Fu et al.,2020).

关 键 词：genomic stabilityby colon cancer therapy ubiquitin ligaseplays smurf hect type e ubiquitin ligase signaling regulatory proteins APOPTOSIS biological processesencompassing 

分 类 号：R73[医药卫生—肿瘤]