能量代谢在中药安全性评价中的研究进展  

Research progress of energy metabolism in safety evaluation of traditional Chinese medicine

作　　者：王雪 翟玉静 田锁燕 赫俊杰 孙璐 刘传鑫 许妍妍[1] WANG Xue;ZHAI Yujing;TIAN Suoyan;HE Junjie;SU Lu;LIU Chuanxin;XU Yanyan(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Luoyang Key Laboratory of Clinical Multiomics and Translational Medicine,Key Laboratory of Hereditary Rare Diseases of Health Commission of Henan Province,Henan Key Laboratory of Rare Diseases,Endocrinology and Metabolism Center,The First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China;College of Chinese Materia Medica and Food Engineering,Shanxi University of Chinese Medicine,Jinzhong 030619,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]河南科技大学临床医学院,河南科技大学第一附属医院内分泌代谢中心,河南省罕见病重点实验室,河南省卫生健康委遗传罕见病重点实验室,洛阳市临床多组学与转化医学重点实验室,河南洛阳471003 [3]山西中医药大学中药与食品工程学院,山西晋中030619

出　　处：《中草药》2025年第5期1840-1851,共12页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(82004093);国家自然科学基金项目(81873194);国家自然科学基金项目(82204938);河南省医学科技攻关计划联合共建项目(LHGJ20240427)。

摘　　要：中药通过独特的药理作用影响机体的能量代谢过程,在安全性评价中发挥着关键作用。中药能纠正能量代谢失衡,在临床实践中具有重要的治疗价值,然而,其不良反应会导致能量代谢紊乱。聚焦于能量代谢在中药安全性评价中的研究进展,深入探讨外源性、内源性因素如何影响能量代谢,旨在为中药安全性评估与能量代谢的关联提供科学依据。Traditional Chinese medicine(TCM)influences the body's energy metabolism process through its unique pharmacological actions,which plays a key role in safety evaluation.TCM can correct the imbalance of energy metabolism and has important therapeutic value in clinical practice.However,its adverse reactions may lead to energy metabolism disorders.This article focuses on the research progress of energy metabolism in the safety evaluation of TCM,deeply explores how exogenous and endogenous factors affect energy metabolism,and aims to provide a scientific basis for the association between TCM safety assessment and energy metabolism.

关 键 词：能量代谢 中药 安全性评价 中药毒性 体质毒理学 药物警戒 

分 类 号：R28[医药卫生—中药学]