幽门螺杆菌形态与胃炎患者胃病理组织学特征的相关性分析  

Correlation analysis of Helicobacter pylori morphology with gastric pathological histological features in patients with gastritis

作　　者：胡孝霞 王雅雅 李玲[1] 何鑫 张世杨 HU Xiaoxia;WANG Yaya;LI Ling;HE Xin;ZHANG Shiyang(Department of Gastroenterology,Mianzhu People's Hospital,Mianzhu 618200,Sichuan,china)

机构地区：[1]绵竹市人民医院消化内科,四川绵竹618200

出　　处：《中国病原生物学杂志》2025年第5期569-572,共4页Journal of Pathogen Biology

摘　　要：目的本研究旨在探讨幽门螺杆菌(Helicobacter pylori,Hp)形态与胃炎患者胃病理组织学特征之间的相关性,包括炎症程度、胃黏膜萎缩、肠化生和异型增生。方法对320例胃炎患者的胃黏膜活检标本进行Hp检测,分析其形态,并评估与炎症程度、胃黏膜萎缩、肠化生和异型增生的关系。采用卡方检验分析Hp形态与各病理组织学特征之间的相关性。结果Hp阳性患者共260例,其中螺旋形、球形和混合形的分布分别为156、48和56例。Hp阳性患者的炎症程度普遍高于阴性患者,卡方检验结果显示,不同形态的Hp与炎症程度之间存在显著的统计学关联(χ^(2)=7.017,P=0.008)。Hp形态与胃黏膜萎缩的相关性显著(χ^(2)=22.86,P<0.001)。Hp形态与胃黏膜肠化生之间也存在显著的相关性(χ^(2)=14.28,P<0.05)。而对于异型增生,Hp形态与胃黏膜异型增生之间无显著相关性(χ^(2)=3.38,P>0.05)。结论Hp的形态与胃炎患者的胃病理组织学特征密切相关,特别是与炎症程度、胃黏膜萎缩和肠化生的关系。这些结果为理解Hp感染的致病机制提供了新的视角,并可能对临床治疗策略和胃癌预防措施的制定有所帮助。Objective This study aimed to explore the correlation between the morphology of Helicobacter pylori(Hp)and the pathological features of gastric tissues in patients with gastritis,including the degree of inflammation,gastric mucosal atrophy,intestinal metaplasia,and dysplasia.Methods Hp detection was performed on gastric mucosal biopsy specimens from 320 patients with gastritis,and the morphology was analyzed to assess its relationship with the degree of inflammation,gastric mucosal atrophy,intestinal metaplasia,and dysplasia.Chi-square tests were used to analyze the correlation between Hp morphology and each pathological feature.Results A total of 260 patients tested positive for Hp,with spiral,spherical,and mixed forms distributed as 156,48,and 56 cases,respectively.The degree of inflammation in Hp-positive patients was generally higher than in negative patients.Chi-square test results showed a significant statistical association between different forms of Hp and the degree of inflammation(χ^(2)=7.017,P=0.008).The correlation between Hp morphology and gastric mucosal atrophy was significant(χ^(2)=22.86,P<0.001).There was also a significant correlation between Hp morphology and intestinal metaplasia of the gastric mucosa(χ^(2)=14.28,P<0.05).However,for dysplasia,there was no significant correlation between Hp morphology and gastric mucosal dysplasia(χ^(2)=3.38,P>0.05).Conclusion The morphology of Hp is closely related to the pathological features of gastric tissues in patients with gastritis,especially the degree of inflammation,gastric mucosal atrophy,and intestinal metaplasia.These results provide a new perspective for understanding the pathogenic mechanisms of Hp infection and may be helpful in formulating clinical treatment strategies and gastric cancer prevention measures.

关 键 词：幽门螺杆菌 形态 胃炎 病理组织学特征 相关性分析 

分 类 号：R573[医药卫生—消化系统]