ESRP1在乳腺癌恶性进展中的作用研究进展  

The role of ESRP1 in the development and progression of breast cancer

作　　者：王心怡 宋淑萍 黄建迪 钟文超 李东航 陈定科 孙艳芹 WANG Xinyi;SONG Shuping;HUANG Jiandi;ZHONG Wenchao;LI Donghang;CHEN Dingke;SUN Yanqin(Department of Pathology,Guangdong Medical University,Zhanjiang 524000,Guangdong,China;Department of Pathology,the Affiliated Hospital of Guangdong Medical University;Department of Oncology,Dongguan Songshan Lake Central Hospital,Guangdong Medical University)

机构地区：[1]广东医科大学病理学系,广东湛江524000 [2]广东医科大学附属医院 [3]广东医科大学附属东莞松山湖中心医院

出　　处：《中国病原生物学杂志》2025年第5期683-686,共4页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.81702285);广东省基础与应用基础研究基金(No.2021B1515140067,2022A1515012190);湛江市科技发展专项资金竞争性分配项目(No.2022A01018);广东医科大学临床+基础科技创新专项计划项目(GDMULCJC2024117)。

摘　　要：乳腺癌发病率居于女性恶性肿瘤首位,晚期出现全身转移将显著降低乳腺癌患者生存期,是当前临床治疗的主要挑战之一。RNA可变剪接(AS)在乳腺癌转移过程中起到重要作用,而肿瘤转移过程中具有不同的上皮间充质转换(EMT)过渡状态。上皮剪接调节蛋白1(ESRP1)是一种上皮特异性剪切调节因子,基因特定的选择性剪接事件在肿瘤中非常普遍,通常会导致肿瘤的增殖和转移等进展。在过去,ESRP1被认为扮演着抑制肿瘤的作用。然而最近,ESRP1在肿瘤中的双重作用已被广泛认可。在乳腺癌和卵巢癌中,已经发现了ESRP1促进癌症进展的作用。一般认为ESRP1在EMT期间下调并调节靶基因的选择性剪接从而参与EMT。然而,最近的研究表明,在乳腺癌中,ESRP1与乳腺癌中改变的EMT表型没有直接关系,ESRP1敲低诱导乳腺癌中的EMT可能需要适当的背景条件。此外,最近的研究强调了ESRP1在乳腺癌代谢途径中的重要作用。本文就ESRP1在乳腺癌恶性进展中作用的研究进展作一综述旨在为改进乳腺癌的临床治疗策略提供参考。Breast cancer is the leading malignant tumor among females,with systemic metastasis at advanced stages markedly reducing the survival time of patients,posing a significant challenge in current clinical treatment.Alternative splicing(AS)plays a crucial role in the metastatic process of breast cancer,and tumor metastasis exhibits distinct epithelial-mesenchymal transition(EMT)hybrid states.Epithelial splicing regulatory protein 1(ESRP1)serves as an epithelial-specific splicing regulator,and gene-specific alternative splicing events are prevalent in tumors,often leading to progression such as proliferation and metastasis.Historically,ESRP1 was considered to function as a tumor suppressor.However,its dual role in cancer has recently gained widespread recognition.In breast and ovarian cancer,ESRP1 has been found to promote cancer progression.ESRP1 is generally thought to be downregulated during EMT by regulating the alternative splicing of target genes.Nevertheless,recent studies have indicated that in breast cancer,ESRP1 is not directly associated with altered EMT phenotypes;the induction of EMT in breast cancer by ESRP1 knockdown may require appropriate background conditions.Moreover,recent research has highlighted the important role of ESRP1 in breast cancer metabolic pathways.This review aims to summarize the research progress regarding the impact of ESRP1 on the malignant progression of breast cancer,providing a reference for improving clinical treatment strategies for breast cancer.

关 键 词：上皮剪接调节蛋白1 上皮间充质转换 乳腺癌 综述 

分 类 号：R737.9[医药卫生—肿瘤]