iRhom1、iRhom2、TNF-α水平对宫颈癌患者预后的预测价值  

Predictive value of iRhom1,iRhom2 and TNF-αlevels for the prognosis of patients with cervical cancer

作　　者：韩涛[1] 贾沛沛 鲁静[1] Han Tao;Jia Peipei;Lu Jing(Department of Gynecology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院妇科,乌鲁木齐830001

出　　处：《国际肿瘤学杂志》2025年第3期158-162,共5页Journal of International Oncology

摘　　要：目的探究不同预后的宫颈癌患者非活化菱形蛋白(iRhom)1、iRhom2、肿瘤坏死因子α(TNF-α)水平差异,分析各指标对患者预后的预测价值。方法选择2021年6月至2023年6月于新疆维吾尔自治区人民医院行广泛性子宫切除术的90例宫颈癌患者作为研究对象。通过倾向性评分匹配的方法,以0.02卡钳值筛选30例一般临床资料匹配的宫颈活检正常患者作为对照。根据患者预后情况,将宫颈癌患者分为预后良好组(n=69)和预后不良组(n=21)。采用蛋白质印迹法检测组织样本中iRhom1、iRhom2、TNF-α的蛋白水平。比较宫颈癌组织、癌旁组织、正常宫颈组织以及预后良好组与预后不良组iRhom1、iRhom2和TNF-α蛋白水平差异。采用多因素logistic回归分析宫颈癌患者预后的影响因素,采用受试者操作特征(ROC)曲线评价各指标对宫颈癌患者预后的预测效能。结果宫颈癌组织、癌旁组织、正常宫颈组织中iRhom1蛋白水平分别为0.80±0.11、0.41±0.10、0.40±0.07,iRhom2分别为0.81±0.12、0.47±0.10、0.46±0.05,TNF-α分别为1.15±0.12、0.58±0.10、0.56±0.07,3组间iRhom1、iRhom2、TNF-α蛋白水平差异均有统计学意义(F=64.93,P<0.001;F=56.14,P<0.001;F=191.61,P<0.001)。宫颈癌组织与癌旁组织、正常宫颈组织中iRhom1、iRhom2、TNF-α蛋白水平相比,差异均有统计学意义(均P<0.05)。预后不良组、预后良好组宫颈癌组织中iRhom1蛋白水平分别为0.90±0.12、0.77±0.10,iRhom2分别为0.90±0.10、0.79±0.09,TNF-α分别为1.29±0.13、1.06±0.10,两组间iRhom1、iRhom2、TNF-α蛋白水平差异均有统计学意义(t=7.31,P<0.001;t=5.35,P<0.001;t=10.30,P<0.001)。多因素logistic回归分析显示,iRhom1(OR=2.29,95%CI为1.77~3.71,P<0.001)、iRhom2(OR=1.51,95%CI为1.10~2.71,P<0.001)、TNF-α(OR=2.10,95%CI为1.90~4.44,P<0.001)均是宫颈癌患者预后的独立影响因素。ROC曲线显示,iRhom1(AUC为0.88,95%CI为0.80~0.97)、iRhom2(AUC为0.83,95%CI为0.73~0.94)、TNF-αObjective To investigate the differences in the levels of inactive rhomboid protein(iRhom)1,iRhom2,and tumor necrosis factor-α(TNF-α)in cervical cancer patients with different prognoses,and to analyze the predictive value of each index for patient′s prognosis.Methods A total of 90 cervical cancer patients who underwent extensive hysterectomy at the People′s Hospital of Xinjiang Uygur Autonomous Region from June 2021 to June 2023 were selected as the study objects.Using a propensity score matching method with a caliper value of 0.02,30 cases with normal cervical biopsy results and matched general clinical data were selected as the controls.Cervical cancer patients were divided into the good prognosis group(n=69)and the poor prognosis group(n=21)according to the prognosis.Western blotting was used to detect the protein levels of iRhom1,iRhom2,and TNF-αin tissue samples.The differences in iRhom1,iRhom2,and TNF-αprotein levels between cervical cancer tissues,adjacent tissues,normal cervical tissues,and between the good and poor prognosis groups were compared.Multivariate logistic regression was used to analyze the influencing factors of prognosis in cervical cancer patients,and the receiver operator characteristic(ROC)curve was used to evaluate the predictive efficacy of each indicator for prognosis in cervical cancer patients.Results The levels of iRhom1 protein in cervical cancer tissues,adjacent tissues,and normal cervical tissues were 0.80±0.11,0.41±0.10,0.40±0.07,respectively;those of iRhom2 were 0.81±0.12,0.47±0.10,0.46±0.05,respectively;and those of TNF-αwere 1.15±0.12,0.58±0.10,0.56±0.07,respectively.There were statistically significant differences in the levels of iRhom1,iRhom2,and TNF-αprotein among the three groups(F=64.93,P<0.001;F=56.14,P<0.001;F=191.61,P<0.001).There were statistically significant differences in the levels of iRhom1,iRhom2 and TNF-αbetween cervical cancer tissues and adjacent tissues and normal cervical tissues(all P<0.05).In the poor prognosis group and the good pro

关 键 词：宫颈肿瘤 肿瘤坏死因子Α 预后 非活化菱形蛋白 

分 类 号：R737.33[医药卫生—肿瘤]