血管生成与骨肉瘤的相关性研究进展  

Research progress of the correlation between angiogenesis and osteosarcoma

作　　者：蒲文霞 邓宗卓 王培鑫 王秋兰[1] Pu Wenxia;Deng Zongzhuo;Wang Peixin;Wang Qiulan(First School of Clinical Medical,Gansu University of Chinese Medicine,Lanzhou 730000,China;Trauma Center,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省中医院创伤中心,兰州730050

出　　处：《国际肿瘤学杂志》2025年第3期186-189,共4页Journal of International Oncology

基　　金：兰州市科技计划(2023-2-51)。

摘　　要：骨肉瘤是一类间质组织肿瘤,具有高侵袭性和转移性。促血管生成因子、血管内皮细胞在骨肉瘤血管生成和转移中起关键作用,血管内皮细胞与骨肉瘤细胞的相互作用可影响骨肉瘤的生长及转移,骨肉瘤抗血管治疗药物包括单克隆抗体、酪氨酸激酶抑制剂、中药等均可抑制骨肉瘤的进展。深入研究血管生成与骨肉瘤的相关性,可为骨肉瘤血管化研究及骨肉瘤抗血管治疗提供新的思路。Osteosarcoma is a kind of mesenchymal tissue tumor,which is highly invasive and metastatic.Pro-angiogenic factors and vascular endothelial cells play key roles in the angiogenesis and metastasis of osteosarcoma,and the interaction between vascular endothelial cells and osteosarcoma cells can affect the growth and metastasis of osteosarcoma.Anti-vascular therapeutics agents for osteosarcoma,including monoclonal antibodies,tyrosine kinase inhibitors and traditional Chinese medicines,can inhibit the progression of osteosarcoma.An in-depth study of the correlation between osteosarcoma and angiogenesis can provide new ideas for the study of vascularization of osteosarcoma and anti-vascular treatment of osteosarcoma.

关 键 词：骨肉瘤 血管生成诱导剂 内皮细胞 

分 类 号：R738.1[医药卫生—肿瘤]