Accelerometry‑assessed sleep clusters and obesity in adolescents and young adults:a longitudinal analysis in GINIplus/LISA birth cohorts  

作　　者：Mingming Wang Claudia Flexeder Carla PHarris Sara Kress Tamara Schikowski Annette Peters Marie Standl 

机构地区：[1]Institute of Epidemiology,Helmholtz Zentrum München–German Research Center for Environmental Health,Ingolstädter LandstraBe 1,85764 Neuherberg,Germany [2]Institute for Medical Information Processing,Biometry and Epidemiology(IBE),Faculty of Medicine,LMU Munich,Pettenkofer School of Public Health,Munich,Germany [3]Institute and Clinic for Occupational,Social and Environmental Medicine,University Hospital,LMU Munich,Munich,Germany [4]Department of Pediatrics,Dr.Von Hauner Children’s Hospital,LMU University Hospitals,Munich,Germany [5]IUF–Leibniz Research Institute for Environmental Medicine,Düsseldorf,Germany [6]Chair of Epidemiology,Ludwig Maximilians University of Munich,Munich,Germany [7]German Center for Child and Adolescent Health(DZKJ),Partner Site Munich,Munich,Germany

出　　处：《World Journal of Pediatrics》2025年第1期48-61,共14页世界儿科杂志(英文版)

基　　金：Open Access funding enabled and organized by Projekt DEAL;The GINIplus study was mainly supported for the first three years of the Federal Ministry for Education,Science,Research and Technology(intervention arm)and Helmholtz Zentrum München(former GSF)(observation arm);The 4-year,6-year,10-year,15-year and 20-year follow-up examinations of the GINIplus study were covered from the respective budgets of the five study centres(Helmholtz Zentrum München(former GSF),Research Institute at Marien-Hospital Wesel/EVK Düsseldorf,LMU Munich,TU Munich and from six years onwards also from IUF–Leibniz Research-Institute for Environmental Medicine at the University of Düsseldorf)and a grant from the Federal Ministry for Environment(IUF Düsseldorf,FKZ 20462296);Further,the 15-year follow-up examination of the GINIplus study was supported by the Commission of the European Communities,the 7th Framework Program:MeDALL project;The 15-year and 20-year follow-up examinations were in addition supported by the companies Mead Johnson and Nestlé;The LISA study was mainly supported by grants from the Federal Ministry for Education,Science,Research and Technology and in addition from Helmholtz Zentrum München(former GSF),Helmholtz Centre for Environmental Research—UFZ,Leipzig,Research Institute at Marien-Hospital Wesel,Pediatric Practice,Bad Honnef for the first two years;The 4-year,6-year,10-year,15-year and 20-year follow-up examinations of the LISA study were covered from the respective budgets of the involved partners(Helmholtz Zentrum München(former GSF),Helmholtz Centre for Environmental Research–UFZ,Leipzig,Research Institute at Marien-Hospital Wesel,Pediatric Practice,Bad Honnef,IUF—Leibniz-Research Institute for Environmental Medicine at the University of Düsseldorf)and in addition by a grant from the Federal Ministry for Environment(IUF Düsseldorf,FKZ 20462296);Further,the 15-year follow-up examination of the LISA study was supported by the Commission of the European Communities,the 7th Framework Program:MeDALL p

摘　　要：Background Some studies have revealed various sleep patterns in adolescents and adults using multidimensional objective sleep parameters.However,it remains unknown whether these patterns are consistent from adolescence to young adulthood and how they relate to long-term obesity.Methods Seven-day accelerometry was conducted in German Infant Study on the influence of Nutrition Intervention PLUS environmental and genetic influences on allergy development(GINIplus)and Influence of Lifestyle factors on the development of the Immune System and Allergies in East and West Germany(LISA)birth cohorts during the 15-year and 20-year follow-ups,respectively.Five sleep clusters were identified by k-means cluster analysis using 12 sleep characteristics at each follow-up.Adjusted linear and logistic regression models using generalized estimating equations were examined.Further,the interaction effects with time of follow-ups and polygenic risk scores(PRS)for body mass index(BMI)were tested.Results Five sleep clusters were classified consistently in both adolescence(n=1347,aged 14.3–16.4 years)and young adulthood(n=1262,aged 19.5–22.4 years).Adolescents in the“good sleep”,“delayed sleep phase”,and“fragmented sleep”clusters displayed greater stability transitioning into young adulthood,while those in the“sleep irregularity and variability”,and“prolonged sleep latency”clusters showed lower stability(n=636).Compared to the“good sleep”cluster,the“prolonged sleep latency”cluster exhibited associations with higher BMI[β=0.56,95%confidence interval(CI)=(0.06,1.05)]and increased odds of overweight/obesity[Odds ratio=1.55,95%CI=(1.02,2.34)].No significant PRS-sleep cluster interaction was found for BMI or overweight/obesity.Among males only,the“delayed sleep phase”,“sleep irregularity and variability”and“fragmented sleep”clusters showed stronger associations with overweight/obesity as age increased.Conclusion Adolescents and young adults shared five consistent sleep patterns,with the“prolonged

关 键 词：ACCELEROMETRY Adolescents OBESITY Sleep clusters Young adults 

分 类 号：R338.63[医药卫生—人体生理学]