中枢神经淋巴系统解剖及其与神经系统疾病关系  

Recent advances in anatomy of central nervous lymphatic system and the relationship between it and nervous system diseases

作　　者：范咏言 何培坤 李彦颐 王丽娟[1] 聂坤[1] Fan Yongyan;He Peikun;Li Yanyi;Wang Lijuan;Nie Kun(Department of Neurology,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学附属广东省人民医院(广东省医学科学院)神经科,广东广州510515

出　　处：《中国临床解剖学杂志》2025年第2期151-156,共6页Chinese Journal of Clinical Anatomy

基　　金：国家自然科学基金(82471257,82371249);广东省自然科学基金(2025A1515012506);广东省科技计划项目(2023B110009);广州市科技计划项目(202201000005)。

摘　　要：近年来,中枢神经淋巴系统是神经科学研究的热点。中枢神经淋巴系统主要由星形胶质细胞足突围绕血管壁形成的胶质淋巴系统,以及脑膜静脉窦伴行的脑膜淋巴管组成,具有代谢废物清除、免疫功能、信号转导、物质运输和药物递送等功能,并受到水通道蛋白4、血流动力学、睡眠与昼夜节律等因素的调控。同时,该系统与神经退行性疾病、中枢神经系统脱髓鞘疾病、脑血管病等神经系统疾病的发生发展密切相关。本综述围绕中枢神经淋巴系统的解剖学结构、功能及其在神经系统疾病中的作用进行回顾,总结近年来的研究进展。Central nervous lymphatic system is an important breakthrough in neuroscience research in recent years.The anatomical structure of central nervous lymphatic system mainly includes glial lymphatic system formed around blood vessel wall of astrocyte foot process,and meningeal lymphatic vessels associated with meningeal venous sinus,which have metabolic waste clearance,immune function,signal transduction,material transport and drug delivery,and are regulated by AQP4,hemodynamics,sleep,and circadian rhythm and other factors.At the same time,the system is closely related to neurodegenerative diseases,central nervous system demyelinating diseases,cerebrovascular diseases,and other neurological diseases.This review focuses on anatomical structure,function,and role of nervous system diseases,and summarizes the research progress in recent years.

关 键 词：中枢神经淋巴系统 胶质淋巴系统 脑膜淋巴管 神经系统疾病 

分 类 号：R742.5[医药卫生—神经病学与精神病学]