表观遗传修饰调控牙髓炎症和再生的研究进展  

Research Progress on Epigenetic Modifications Regulating Regeneration of Dental Pulp Inflammation

作　　者：苏芊芊 胡涛[1] SU Qianqian;HU Tao(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Frontier Innovation Center for Dental Medicine Plus&Department of Preventive Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]国家口腔医学中心国家口腔疾病临床医学研究中心、口腔疾病防治全国重点实验室、口腔医学+前沿医学创新中心、四川大学华西口腔医院预防口腔科,四川成都610041

出　　处：《口腔医学研究》2025年第4期269-275,共7页Journal of Oral Science Research

基　　金：国家自然科学基金区域重点项目(编号:U20A20365)。

摘　　要：牙髓可能由于龋病、外伤等原因导致不可逆的损伤。目前临床针对牙髓炎的治疗方法多为根管治疗,然而根管治疗存在一定的局限性,研究和开发保存牙髓的治疗方案势在必行。表观遗传修饰主要包括DNA甲基化、组蛋白甲基化、组蛋白乙酰化、非编码RNA等,可在不改变遗传基因的情况下调控细胞状态。随着表观遗传学的深入研究,其在牙髓炎症和再生中应用取得了一定突破,本文将就表观遗传修饰在促进牙髓炎症和再生的研究进展作一综述。The dental pulp may suffer irreversible damage due to reasons such as dental caries and trauma.Currently,most clinical treatments for pulpitis are root canal therapy.However,root canal therapy has certain limitations,and research and development of pulp-preserving treatment options are imperative.Epigenetic modifications,which mainly include DNA methylation,histone methylation,histone acetylation,and non-coding RNAs,can regulate cellular states without altering genes.With the in-depth study of epigenetics,its application in the inflammatory regeneration of dental pulp has made certain breakthroughs.This paper will provide an overview of the research progress on the application of epigenetic modifications in the treatment of dental pulp inflammatory regeneration.

关 键 词：表观遗传 牙髓 炎症 修复 再生 

分 类 号：R781.3[医药卫生—口腔医学]