Human papillomavirus negative cervical cancers and precancerous lesions:prevalence,pathological and molecular features,and clinical implications  

作　　者：Wenli Dai Xianxu Zeng Liron Pantanowitz Chengquan Zhao 

机构地区：[1]Departmentof Pathology,University of Pittsburgh School of Medicine,Pittsburgh,Pennsylvania,USA [2]Pathology,The Third Affiliated Hospitalof Zhengzhou University,Zhengzhou,Henan,China

出　　处：《Gynecology and Obstetrics Clinical Medicine》2025年第1期64-71,共8页妇产科临床医学(英文)

摘　　要：Background:Cervical cancer is the fourth most common cancer in women gobally.Although human paillonavinus(HPV)testing plays an increasing role in cervical cancer screening and treatment,HPV-negative cervical cancer remains a consistenty reported entity globally.Whle numerous studies have focused on HPV-positve cervical cancers,detailed studies on HPV-negative counterparts remain limited.Results:This literature review aims to discuss several aspects of HPV-negative cervical cancers including the prevalence of HPV-negative cervical carcinomas and precancerous lesions and their relation to sample types(parffin-embedded tsse blocks or liquid samples).Addionally.we explore possible reasons for false HPV-negative cases.Furthermore,we review histomorphological,molecular and cdinical features of HPV-negative cervical cancers.Conclusions:The topic of HPV-negative cervical cancers is of importance given the drive towards HPV primary screening,itition of self-collected HPV testing and widespread use of HPV vaccination.

关 键 词：human papillomavirus negative cervical cancer pathological features human paillonavinus hpv testing PREVALENCE molecular features literature review self collected HPV testing cervical cancer 

分 类 号：R737.33[医药卫生—肿瘤]