Behavioral Animal Models and Neural-Circuit Framework of Depressive Disorder  

作　　者：Xiangyun Tian Scott J.Russo Long Li 

机构地区：[1]State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing,100101,China [2]University of the Chinese Academy of Sciences,Beijing,100049,China [3]Nash Family Department of Neuroscience,Icahn School of Medicine at Mount Sinai,New York,NY,10029,USA [4]Friedman Brain Institute,Icahn School of Medicine at Mount Sinai,New York,NY,10029,USA

出　　处：《Neuroscience Bulletin》2025年第2期272-288,共17页神经科学通报(英文版)

基　　金：supported by the Brain&Behavior Research Foundation(30233).

摘　　要：Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.

关 键 词：DEPRESSION Animal models STRESS Neural circuits 

分 类 号：R749.4[医药卫生—神经病学与精神病学]