血清KLF7、CA15-3在宫颈癌诊断及预后评估中的临床意义  

Clinical significance of serum KLF7 and CA15-3 in the diagnosis and prognosis evaluation of cervical cancer

作　　者：王瑾[1] 刘淑君[1] 蒋天从 WANG Jin;LIU Shujun;JIANG Tiancong(Department of Obstetrics and Gynecology,Tangshan Traditional Chinese Medicine Hospital,Tangshan 063000,China)

机构地区：[1]唐山市中医医院妇产科,河北唐山063000 [2]唐山市妇幼保健院妇产科,063000

出　　处：《临床肿瘤学杂志》2025年第2期156-160,共5页Chinese Clinical Oncology

基　　金：河北省中医药类科研计划课题(2021395)。

摘　　要：目的探讨血清Krüppel样因子7(KLF7)、糖类抗原15-3(CA15-3)水平在宫颈癌早期诊断及预后评估中的临床意义。方法收集唐山市中医医院2020年3月至2022年3月期间收治的127例宫颈癌初诊患者(宫颈癌组)和89例宫颈良性病变患者(良性病变组)作为研究对象,另选取同期体检健康者76例作为健康对照组。随访至截止时间,根据生存情况分为生存组(106例)、死亡组(21例);收集宫颈癌患者的临床病历资料。采用酶联免疫吸附(ELISA)法检测各组血清KLF7表达水平,电化学发光免疫分析(ECLIA)法检测血清CA15-3水平;分析宫颈癌患者血清KLF7、CA15-3水平与患者临床病理特征的关系;采用受试者工作特征(ROC)曲线评估KLF7、CA15-3水平对宫颈癌的诊断价值及其对患者预后的预测价值。结果宫颈癌组血清KLF7、CA15-3水平明显高于良性病变组、健康对照组(P<0.05);FIGO分期ⅡA期、宫颈浸润深度≥2/3、HPV感染、淋巴结转移、低分化的宫颈癌患者血清KLF7、CA15-3水平高于ⅠA~ⅠB期、宫颈浸润深度<2/3、无HPV感染、无淋巴结转移、中高分化患者(P<0.05);死亡组患者血清KLF7、CA15-3水平明显高于生存组(P<0.05);ROC曲线分析结果显示,血清KLF7、CA15-3水平联合检测对诊断宫颈癌及预测患者预后不良的效果优于二者单独检测(P<0.05);Cox回归分析显示,低分化、FIGO分期为ⅡA期、HPV感染、宫颈浸润深度≥2/3、淋巴结转移及KLF7、CA15-3水平升高是影响宫颈癌患者预后的独立因素(P<0.05)。结论宫颈癌患者血清KLF7、CA15-3水平均明显升高,二者联合进行宫颈癌诊断时价值更高,且其水平与宫颈癌患者临床病理特征及预后密切相关。Objective To explore the clinical significance of serum levels of Krüppel-like factor 7(KLF7)and carbohydrate antigen 15-3(CA15-3)in the early diagnosis and prognosis evaluation of cervical cancer.Methods A total of 127 newly diagnosed patients with cervical cancer(cervical cancer group)and 89 patients with benign cervical lesions(benign cervical lesion group)admitted to our hospital from March 2020 to March 2022 were regarded as the research subjects,and 76 healthy individuals who underwent physical examination were as the healthy control group.Follow-up to deadline,the patients were divided into survival group and death group,106 cases and 21 cases respectively.The clinical characteristic data of cervical cancer patients were collected.ELISA method was applied to detect the expression level of KLF7 in serum of each group,and ECLIA method was applied to detect the level of CA15-3 in serum.The relationship between serum KLF7,CA15-3 levels and clinical pathological characteristics of cervical cancer patients was analyzed.The receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of KLF7 and CA15-3 levels for cervical cancer and their predictive value for poor prognosis.Results The serum levels of KLF7 and CA15-3 in the cervical cancer group were greatly higher than those in the benign lesion group and healthy control group(P<0.05);the serum KLF7 and CA15-3 levels in patients with FIGO stageⅡA,cervical infiltration depth≥2/3,HPV infection,lymph node metastasis,and poorly differentiated cervical cancer were higher than those in patients with stageⅡA-ⅠB,cervical infiltration depth<2/3,no HPV infection,no lymph node metastasis,and medium to high differentiation(P<0.05).The serum levels of KLF7 and CA15-3 in the death group were obviously higher than those in the survival group(P<0.05).ROC curve analysis results showed that the combined detection of serum KLF7 and CA15-3 levels was better than the single detection of the two in diagnosing cervical cancer and predicting poor pr

关 键 词：宫颈癌 Krüppel样因子7 糖类抗原15-3 临床病理特征 预后 

分 类 号：R737.3[医药卫生—肿瘤]