E2Fs在宫颈癌中的作用及机制研究进展  

Research progress on the role and mechanism of E2Fs in cervical cancer

作　　者：马月月 温松泉 赵卫红[2] MA Yueyue;WEN Songquan;ZHAO Weihong(Academy of Medical Sciences,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学医学科学院,山西太原030001 [2]山西医科大学第二医院妇产科,030001

出　　处：《临床肿瘤学杂志》2025年第2期190-194,共5页Chinese Clinical Oncology

基　　金：山西省自然科学基金(202403021211181);山西省卫生健康委员会科研项目(2023056);山西省留学基金委科研项目(2022-195);山西省研究生教育教学改革项目(2022YJJG105);山西省优秀青年基金项目(201901d211506);中国博士后科学基金项目(2019M651072)。

摘　　要：E2Fs是细胞周期的重要调节因子,它们通过控制参与DNA复制和细胞周期进程的众多靶基因的转录来调节细胞周期的各个阶段。E2F家族大致可分为转录激活因子(E2F1、E2F2和E2F3a)和转录抑制因子(E2F3b、E2F4、E2F5、E2F6、E2F7和E2F8)两大类,不仅在调控正常细胞周期中发挥重要作用,而且在宫颈癌中也有着不容忽视的影响。E2Fs作为效应分子参与了宫颈癌的发生发展,并且在作为宫颈癌的预后生物标志物和潜在的治疗靶点方面也有着良好的前景。这篇综述总结了近些年来各个E2F家族成员在宫颈癌中的作用及其机制研究进展,以期为宫颈癌的诊治提供新的思路。E2F transcription factors are essential regulators of the cell cycle,regulating the phases of the cell cycle by controlling the transcription of numerous target genes involved in DNA replication and cell cycle progression.The E2F family can be broadly divided into transcriptional activators(E2F1,E2F2,and E2F3a)and transcriptional repressors(E2F3b,E2F4,E2F5,E2F6,E2F7,and E2F8).They play an influential role not only in regulating the normal cell cycle but also have an impact on cervical cancer.As effector molecules,E2Fs are involved in the development and progression of cervical cancer and show promising potential as prognostic biomarkers and therapeutic targets for cervical cancer.This review summarizes the research progress on the role and mechanism of various E2F family members in cervical cancer in recent years,in order to provide current ideas for the diagnosis and treatment of cervical cancer.

关 键 词：子宫颈肿瘤 E2Fs 转录因子 机制 研究进展 

分 类 号：R737.33[医药卫生—肿瘤]