650 nm低强度单波长红光照射对不同近视度数青少年近视防控的应用效果对比研究  

Comparative study on application effect of 650-nm low-intensity single-wavelength red light irradiation on myopia prevention and control in adolescents with different myopia degrees

作　　者：范大伟 张伟亮 杨璐 杨晶 杜梁 Fan Dawei;Zhang Weiliang;Yang Lu;Yang Jing;Du Liang(Department of Ophthalmology,Xin'an International Hospital,Jiaxing,Zhejiang 314000,China;Department of Ophthalmology,Shanxi Norman Bethune Hospital,Taiyuan,Shanxi 030032,China;Aier Eye Hospital,Changzhi,Shanxi 046000,China)

机构地区：[1]浙江新安国际医院眼科,浙江嘉兴314000 [2]山西白求恩医院眼科,山西太原030032 [3]长治市爱尔眼科医院,山西长治046000

出　　处：《齐齐哈尔医学院学报》2025年第7期640-645,共6页Journal of Qiqihar Medical University

摘　　要：目的 评估650 nm低强度单波长红光照射对不同近视度数青少年的疗效。方法 选择2022年1—12月本院眼科诊断为近视的青少年患者作为研究对象,分析无远视储备的正视眼(正视眼组)、轻度近视(<-3.00D,轻度近视组)、中度近视(-3.00D~6.00D,中度近视组)、高度近视(>-6.00D,高度近视组)青少年(7~6岁)各60例(眼),在应用650 nm低强度单波长红光照射干预前、干预后(1个月、3个月、6个月、12个月)眼轴长度(AL)、等效球镜(SE)、后极部黄斑中心凹下脉络膜厚度(SFCT)的变化。结果 4组患者AL的变化依次为(-0.254±0.034)mm,(0.173±0.102)mm,(0.161±0.127)mm,(-0.018±0.082)mm,P=0.015,差异具有统计学意义(P<0.05)。随近视度的增加,650 nm红光对AL的控制效果逐渐增强,其中高度近视眼组控制效果最佳。SE比较,相对于干预前,正视眼组、高度近视组变化值差异均无统计学意义(F_(正视眼组)=1.012,P_(正视眼组)=0.250;F_(高度近视组)=1.057,P_(高度近视组)=0.245);低度近视组、中度近视组变化值差异具有统计学意义(F_(轻度近视组)=4.426,P_(轻度近视组)=0.042;F_(中度近视组)=6.215,P_(中度近视组)<0.01)。说明650 nm红光对低中度患者SE的控制效果相对较差。后极部黄斑中心凹下脉络膜厚度(SFCT)比较,4组患者相对于干预前均有增长,其变化依次为(33.56±18.28)μm,(44.37±11.82)μm,(48.22±20.17)μm,(61.27±17.35)μm,差异均具有统计学意义(P<0.05)。650 nm红光对SFCT均有刺激增厚的作用,其中高度近视组最厚,正视眼组最薄。结论 650 nm低强度单波长红光照射对不同近视度数青少年近视防控效果各不相同,从近视整体控制效果来看,近视度数越高,其控制效果越好,随近视度数降低,其控制效果也逐渐减弱。Objective To evaluate the therapeutic effect of 650-nm low-intensity single-wavelength red light irradiation on adolescents with different degrees of myopia.Methods Adolescents diagnosed with myopia by our department of ophthalmology were selected as the subjects of this study.Adolescents(7-16 years old)were divided into emmetropia with no hyperopia reserve(Group 1),mild myopia(<-3.00D,Group 2),moderate myopia(-3.00D to-6.00D,Group 3),and high myopia(>-6.00D,Group 4),with 60 cases in each group.Changes in axial length(AL),equivalent spherical lens(SE),and subfoveal macular choroidal thickness(SFCT)were analyzed in each group before and after intervention with 650-nm low-intensity single-wavelength red light irradiation(1 month,3 months,6 months,and 12 months).Results The difference in AL changes among the four groups of patients was statistically significant[(-0.254±0.034)mm,(0.173±0.102)mm,(0.161±0.127)mm,(-0.018±0.082)mm,P=0.015].The control effect of 650-nm red light on AL gradually strengthened as the degree of myopia increased,with the best effect shown in the high myopia group.There was no statistically significant difference in the change values of SE between the emmetropia group and the high myopia group compared to before intervention(F1=1.012,P1=0.250;F4=1.057,P4=0.245).There was a statistically significant difference in the change values of SE between the low myopia group and the moderate myopia group(F2=4.426,P2=0.042;F3=6.215,P3<0.01).The control effect of 650-nm red light on SE in patients with low to moderate degrees of myopia was relatively poor.Compared to SFCT,all four groups of patients showed growth compared to before intervention,and the differences in their changes were statistically significant[(33.56±18.28)um,(44.37±11.82)um,(48.22±20.17)um,(61.27±17.35)um,P<0.01].650-nm red light had a stimulating and thickening effect on SFCT,with the thickest in the highly myopic group and the thinnest in the emmetropic group.Conclusions The effect of 650-nm low-intensity single-wavelength red l

关 键 词：650 nm低强度红光 近视防控 眼轴 等效球镜 后极部黄斑中心凹下脉络膜厚度 

分 类 号：R778.1[医药卫生—眼科]