饮食因素对肠易激综合征的影响:两样本孟德尔随机化研究  

Analysis of the effect of dietary factors on irritable bowel syndrome by Mendelian randomized method

作　　者：张惠芳 汪彦平 王慧敏 马小彤 郭庆红[2,3] 陈兆峰 ZHANG Huifang;WANG Yanping;WANG Huimin;MA Xiaotong;GUO Qinghong;CHEN Zhaofeng(The First Clinical Medical School,Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,The First Hospital of Lanzhou University,Lanzhou 730000,China;Gansu Clinical Medical Research Center for Digestive Diseases,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院消化内科,兰州730000 [3]甘肃省消化系疾病临床医学研究中心,兰州730000

出　　处：《医学新知》2025年第4期376-385,共10页New Medicine

基　　金：甘肃省科技计划联合科研基金重大项目(23JRRA1487)。

摘　　要：目的通过孟德尔随机化(Mendelian randomization,MR)分析探讨饮食因素与肠易激综合征(irritable bowel syndrome,IBS)发生风险之间的因果关系。方法选择并提取已发表的全基因组关联研究(Genome-Wide Association Study,GWAS)中的饮食因素相关特征作为工具变量,同时从FinnGen数据库获取IBS的GWAS数据,采用逆方差加权法(inverse variance weighted,IVW)作为主要方法进行两样本MR分析,并进行异质性检验、多效性检验以及敏感性分析。结果IVW分析发现,啤酒和苹果酒平均每周摄入量的增多可能会显著增加IBS的发病风险[OR=2.043,95%CI(1.126,3.708),P=0.019],而咖啡[OR=0.671,95%CI(0.473,0.952),P=0.025]和干果[OR=0.452,95%CI(0.293,0.697),P<0.001]摄入量的增加则可能与IBS发病风险的降低相关,其中干果摄入量的结果在加权中位数法分析中也显示出了相似的因果关系[OR=0.427,95%CI(0.231,0.787),P=0.006]。结论啤酒和苹果酒平均每周摄入量以及咖啡、干果的摄入量均与IBS的发病风险存在因果关系,强调在预防IBS方面,合理饮食具有重要作用。Objective To explore the causal relationship between dietary factors and the risk of developing irritable bowel syndrome(IBS)through Mendelian randomization analysis.Methods In the study,dietary factor-related characteristics from published Genome-Wide Association Study(GWAS)were selected and extracted as instrumental variables,and GWAS data on IBS were obtained from FinnGen Database.A two-sample Mendelian randomization analysis was primarily performed using the inverse variance weighted(IVW)method,and the test of heterogeneity,the test of pleiotropy,and sensitivity analyses were performed to guarantee the stability and reliability of the results.Results The results of IVW method showed that an increase in the average weekly beer and cider intake might significantly increase the risk of developing IBS[OR=2.043,95%CI(1.126,3.708),P=0.019].Conversely,an increase in coffee consumption[OR=0.671,95%CI(0.473,0.952),P=0.025]and dried fruits intake[OR=0.452,95%CI(0.293,0.697),P<0.001]appeared to correlate with a decreased risk of developing IBS,where the results for dried fruit intake showed a similar pattern of results in the weighted median method analysis[OR=0.427,95%CI(0.231,0.787),P=0.006].Conclusion The findings suggest a causal relationship between the average weekly intake of beer and cider,coffee,dried fruit and the risk of developing IBS.These findings emphasize the importance of making sound dietary choices in the prevention of IBS.

关 键 词：饮食因素 肠易激综合征 孟德尔随机化 全基因组关联研究 

分 类 号：R574[医药卫生—消化系统]