肝纤维化中T淋巴细胞对肝星状细胞活化的影响  

Effect of T lymphocyte on hepatic stellate cell activation in liver fibrosis

作　　者：龚晓倩 魏业煌 王蓉蓉 刘旭东[2] GONG Xiaoqian;WEI Yehuang;WANG Rongrong;LIU Xudong(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Liver Disease,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,China)

机构地区：[1]广西中医药大学研究生院,南宁530001 [2]广西中医药大学附属瑞康医院肝病科,南宁530011

出　　处：《医学新知》2025年第4期469-475,共7页New Medicine

基　　金：国家自然科学基金地区科学基金项目(82160837);广西中医药大学岐黄工程高层次人才团队培养项目(桂中医大人(2021)10号);全国中医临床优秀人才研修项目(国中医药人教函[2022]1号)。

摘　　要：肝纤维化是由多种病因(如病毒性肝炎和代谢功能障碍相关的脂肪肝病等)引起的肝损伤后机体整体参与的修复反应。其主要表现为肝脏内细胞外基质的过度增生与沉积,从而导致肝脏组织结构异常改变,进而引发肝硬化和肝衰竭,严重损害肝脏正常生理功能。活化的肝星状细胞(hepatic stellate cell,HSC)是形成肝纤维化的主要细胞类型。在肝纤维化过程中,免疫细胞(如Th17、Th1/Th2细胞、Tregs等)在调节HSC活化中起重要作用,并通过细胞因子(如IL-17、IL-10和TGF-β)调节参与HSC活化影响肝纤维化。本文主要介绍T淋巴细胞对HSC活化的调控以及在纤维化中的影响,以拓展调节肝纤维化的潜在治疗方法。Liver fibrosis is a repair reaction of the whole body after liver injury caused by many causes(such as viral hepatitis and metabolic dysfunction-associated steatotic liver disease).It is mainly manifested as excessive proliferation and deposition of extracellular matrix in liver tissue,which leads to abnormal changes in liver tissue structure,cirrhosis and liver failure,and affects the normal physiological function of liver.Activated hepatic stellate cells(HSC)are generally considered to be the main cell type that forms liver fibrosis.During liver fibrosis,immune cells play an important role in regulating the activation of HSC,such as interleukin 17(IL-17),IL-10 and transforming growth factorβ,which are secreted by immune cells in the liver,including helper T cells 17,Th1/Th2 cells,and regulatory T cells.This paper mainly introduces the regulation of T lymphocytes on HSC activation and its impact in fibrosis to expand potential therapeutic approaches to modulate liver fibrosis.

关 键 词：T淋巴细胞 肝纤维化 肝星状细胞 免疫微环境 

分 类 号：R575.2[医药卫生—消化系统]