乳酸化修饰在动脉粥样硬化中的研究进展  

Research progress on lactylation in atherosclerosis

作　　者：莫钦 蓝翊宁 秦超[2] MO Qin;LAN Yining;QIN Chao(Nanning First People’s Hospital,Nanning 530021,China;The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]南宁市第一人民医院,南宁530021 [2]广西医科大学第一附属医院,南宁530021

出　　处：《广西医科大学学报》2025年第2期304-308,共5页Journal of Guangxi Medical University

基　　金：广西自然科学基金重点项目资助(区域高发病专项-广西医科大学)(No.2025GXNSFDA069030);广西研究生教育创新计划项目资助(No.YCBZ2024137)。

摘　　要：动脉粥样硬化(AS)是心脑血管疾病的主要病理基础。乳酸化是一种与乳酸分子相关的新型蛋白质翻译后修饰(PTM),是连接代谢和表观调控的桥梁,通过影响不同的途径参与许多关键的细胞生物过程,与疾病的发展密切相关。最新研究表明,乳酸化修饰可能参与了AS的发生发展。本文旨在概述乳酸化修饰的生物学特性,重点阐述乳酸化修饰在调节内皮细胞功能、巨噬细胞极化和平滑肌衰老等途径参与AS的机制。Atherosclerosis(AS)serves as the primary pathological basis for cardiovascular and cerebrovascular diseases.Lactylation,a novel post-translational modification(PTM)linked to lactate molecules,functions as a critical interface between cellular metabolism and epigenetic regulation.This modification influences diverse pathways to regulate essential biological processes and has been closely associated with disease progression.Emerging evidence suggests that lactylation may participate in the pathogenesis of AS.This paper aims to summarize the biological characteristics of lactylation,and then specifically emphasizes the mechanisms by which lactylation participates in the development of AS through regulating endothelial cell function,macrophage polarization,and smooth muscle cell senescence.

关 键 词：动脉粥样硬化 乳酸化修饰 心脑血管疾病 

分 类 号：R743.31[医药卫生—神经病学与精神病学]