血清Gas6、SDF-1对重症急性胰腺炎患者发生腹腔感染的诊断价值  

Diagnostic value of serum Gas6 and SDF-1 in the occurrence of abdominal infection in patients with severe acute pancreatitis

作　　者：于宁[1] 王景彬 刘欣[2] 张欣[1] 卢毅 闫宝宝 YU Ning;WANG Jingbin;LIU Xin;ZHANG Xin;LU Yi;YAN Baobao(Department 5 of General Surgery,Baoding First Central Hospital,Baoding,Hebei,071030,China;Department of Laboratory,Baoding First Central Hospital)

机构地区：[1]保定市第一中心医院普通外五科,河北保定071030 [2]保定市第一中心医院(西院)检验科

出　　处：《临床急诊杂志》2025年第3期214-218,共5页Journal of Clinical Emergency

基　　金：保定市科技计划项目(No:2341ZF247)。

摘　　要：目的:探讨血清生长停滞特异性蛋白6(growth arrest specific protein 6,Gas6)、基质细胞衍生因子-1(stromal cell-derived factor-1,SDF-1)对重症急性胰腺炎(severe acute pancreatitis,SAP)患者发生腹腔感染的诊断价值。方法:选取2021年11月—2023年11月收治的112例发生腹腔感染的SAP患者为研究对象(研究组),选择本院同期收治的118例SAP未发生腹腔感染患者作为对照组。采用ELISA试剂盒测定2组患者血清Gas6、SDF-1的水平,采用全自动血液分析仪测定患者血清降钙素原(procalcitonin,PCT)、C-反应蛋白(C-reactive protein,CRP)和D-二聚体的水平,收集临床资料。采用Pearson分析血清Gas6、SDF-1水平与PCT、CRP、D-二聚体的相关性,采用多因素logistic回归分析影响SAP患者发生腹腔感染的因素,采用ROC分析血清Gas6、SDF-1水平对SAP患者发生腹腔感染的诊断价值。结果:2组间性别、年龄、合并器官功能不全或衰竭情况比较,差异无统计学意义(P>0.05);研究组入院时Rason评分、PCT、住院天数、CRP、D-二聚体、入院时急性生理与慢性健康评分及血清Gas6、SDF-1水平均明显高于对照组,差异有统计学意义(P<0.05);研究组血清Gas6、SDF-1水平与PCT、CRP、D-二聚体水平均呈正相关(P<0.05);Gas6和SDF-1水平升高是SAP患者发生腹腔感染的独立危险因素(P<0.05);血清Gas6、SDF-1单独及联合诊断SAP患者发生腹腔感染的曲线下面积分别为0.694、0.743、0.803,二者联合优于Gas6、SDF-1各自单独诊断(Z=3.679、2.508,P<0.001、P=0.012)。结论:发生腹腔感染的SAP患者血清中Gas6、SDF-1水平均升高,血清Gas6、SDF-1水平对于SAP患者发生腹腔感染具有一定的诊断价值。Objective To explore the diagnostic value of serum growth arrest specific protein 6(Gas6)and stromal cell-derived factor-1(SDF-1)in the development of abdominal infection(AI)in patients with severe acute pancreatitis(SAP).Methods A total of 112 SAP patients with AI admitted from November 2021 to November 2023 were collected as the study subjects(study group),and 118 SAP patients who did not develop AI admitted from the same time were regarded as the control group.The serum levels of Gas6 and SDF-1 were measured using ELISA kits,and the levels of serum procalcitonin(PCT),C-reactive protein(CRP),and D-dimer were determined using a fully automated blood analyzer.Clinical data were collected.Pearson correlation analysis was used to assess the relationship between serum Gas6 and SDF-1 levels and PCT,CRP,and D-dimer.Multivariate logistic regression was applied to analyze the factors influencing the occurrence of AI in SAP patients.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic value of serum Gas6 and SDF-1 levels for AI in SAP patients.Results There was no significant difference in gender,age,and combined with organ insufficiency or failure between two groups(P>0.05).The Rason score,PCT,length of hospital stay,CRP,D-dimer,Acute Physiology and Chronic Health Evaluation score on admission,and serum levels of Gas6 and SDF-1 were significantly higher in the study group compared to the control group(P<0.05).Serum levels of Gas6 and SDF-1 in the study group were positively correlated with the levels of PCT,CRP and D-dimer(P<0.05).Elevated levels of Gas6 and SDF-1 were identified as independent risk factors for AI in SAP patients(P<0.05).The area under the curve of serum Gas6 and SDF-1 for diagnosing AI in SAP patients alone and in combination was 0.694,0.743,and 0.803,respectively.The combination of Gas6 and SDF-1 showed superior diagnostic performance compared to either marker alone(Z=3.679,2.508,P<0.001,P=0.012).Conclusion The serum levels of Gas6 and SDF-1 are elevated in SAP pati

关 键 词：重症急性胰腺炎 腹腔感染 生长停滞特异性蛋白6 基质细胞衍生因子-1 诊断 

分 类 号：R576[医药卫生—消化系统]