胃癌患者Hp感染与CyclinD1、CA72-4、P53及肿瘤分期的关系分析  

Analysis of the Relationship between Hp Infection,CyclinD1,CA72-4,P53 and Tumor Stage in Patients with Gastric Cancer

作　　者：黎江锋 朱德兴 徐奕晗 LI Jiang-feng;ZHU De-xing;XU Yi-han(Department of Gastroenterology,Fengshun People's Hospital,Meizhou Guangdong 514300,China)

机构地区：[1]梅州市丰顺县人民医院消化内科,广东梅州514300

出　　处：《中华养生保健》2025年第6期15-18,22,23,共6页CHINESE HEALTH CARE

基　　金：梅州市社会发展科技计划项目(2021C0301046)。

摘　　要：目的探讨胃癌患者中幽门螺杆菌(Hp)感染与细胞周期蛋白D1(CyclinD1)、糖类蛋白72-4(CA72-4)、P53及肿瘤分期的关系。方法选取2021年6月—2024年6月在梅州市丰顺县人民医院就诊的120例胃癌患者作为研究对象,根据Hp感染状态将其分为Hp阳性组(n=30)和Hp阴性组(n=30)。采用改良Giemsa染色法及13C呼气试验检测Hp感染,并通过免疫组化方法评估CyclinD1和P53的阳性表达率,电化学发光免疫分析法检测CA72-4水平。采用Spearman相关性分析探讨Hp感染与CyclinD1、CA72-4和P53的关系。结果Hp阳性组的CyclinD1阳性率、P53阳性率、CA72-4水平均高于Hp阴性组,差异有统计学意义(P<0.05)。两组的肿瘤分期比较,差异无统计学意义(P>0.05)。Spearman相关性分析显示,Hp感染基线超基准(DOB)值与CyclinD1(r=0.781,P=0.004)、CA72-4(r=0.553,P=0.002)呈正相关,而与P53(r=-0.362,P=0.041)呈负相关。结论Hp感染与胃癌患者的CyclinD1、CA72-4、P53表达水平关系密切,但与肿瘤分期无关。Objective To investigate the relationship between Helicobacter pylori(Hp)infection and cell cycle protein D1(CyclinD1),carbohydrate protein 72-4(CA72-4),P53 and tumor stage in patients with gastric cancer.Methods 120 patients with gastric cancer diagnosed and treated in our hospital from June 2021 to June 2024 were divided into HP-positive group(n=30)and HP-negative group(n=30)according to their Hp infection status.Hp infection was detected by modifi ed Giemsa staining and 13C breath test.The positive expression rates of CyclinD1 and P53 were evaluated by immunohistochemistry,and the levels of CA72-4 were detected by electrochemiluminescence immunoassay.Spearman correlation analysis was used to investigate the relationship between Hp infection and CyclinD1,CA72-4 and P53.Results The positive rates of CyclinD1,P53 and CA72-4 in HP-positive group were higher than HP-negative group,and the diff erences were statistically signifi cant(P<0.05).There was no diff erence in tumor stage between the two groups(P>0.05).Spearman correlation analysis showed that baseline superbaseline(DOB)of Hp infection was positively correlated with CyclinD1(r=0.781,P=0.004)and CA72-4(r=0.553,P=0.002),but negatively correlated with P53(r=-0.362,P=0.041).Conclusion Hp infection is closely related to the expression levels of CyclinD1,CA72-4 and P53 in gastric cancer patients,but not related to tumor stage.

关 键 词：幽门螺杆菌 胃癌 细胞周期蛋白D1 糖类蛋白72-4 P53 肿瘤分期 

分 类 号：R735.2[医药卫生—肿瘤]